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- W2675278942 abstract "Fanconi anemia (FA), the most common form of inherited bone marrow failure, predisposes to leukemia and solid tumors. FA is caused by the genetic disruption of a cellular pathway that repairs DNA interstrand crosslinks. The impaired function of this pathway, and the genetic instability that results, is considered the main pathogenic mechanism behind this disease. The identification of breast cancer susceptibility genes (for example, BRCA1/FANCS and BRCA2/FANCD1) as being major players in the FA pathway has led to a surge in molecular studies, resulting in the concept of the FA-BRCA pathway. In this review, we discuss recent advances in the molecular pathogenesis of FA from three viewpoints: (a) new FA genes, (b) modifier pathways that influence the cellular and clinical phenotypes of FA and (c) non-canonical functions of FA genes that may drive disease progression independently of deficient DNA repair. Potential therapeutic approaches for FA that are relevant to each will also be proposed." @default.
- W2675278942 created "2017-06-30" @default.
- W2675278942 creator A5015425440 @default.
- W2675278942 creator A5036540850 @default.
- W2675278942 date "2017-06-19" @default.
- W2675278942 modified "2023-09-30" @default.
- W2675278942 title "Recent insights into the molecular basis of Fanconi anemia: genes, modifiers, and drivers" @default.
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- W2675278942 cites W1576573501 @default.
- W2675278942 cites W1742238700 @default.
- W2675278942 cites W1924945038 @default.
- W2675278942 cites W1940231728 @default.
- W2675278942 cites W1967402966 @default.
- W2675278942 cites W1967837680 @default.
- W2675278942 cites W1972104861 @default.
- W2675278942 cites W1980676055 @default.
- W2675278942 cites W1987871280 @default.
- W2675278942 cites W1990556747 @default.
- W2675278942 cites W1991841649 @default.
- W2675278942 cites W1996443829 @default.
- W2675278942 cites W1998984090 @default.
- W2675278942 cites W2000867649 @default.
- W2675278942 cites W2000899081 @default.
- W2675278942 cites W2004189753 @default.
- W2675278942 cites W2005567329 @default.
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- W2675278942 cites W2021850575 @default.
- W2675278942 cites W2040597727 @default.
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- W2675278942 cites W2058004298 @default.
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- W2675278942 doi "https://doi.org/10.1007/s12185-017-2283-4" @default.
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