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- W26754050 abstract "Sarcomas are the third most common group of malignancies in children. The current treatment strategies for sarcoma patients are outdated, have severe side-effects and increase the probability of secondary neoplasms. Clinical benefit from therapy has reached a plateau and local recurrence is still a major problem. Altering the traditionally held view of sarcomagenesis as a purely genetic disease to accommodate the more recent cancer stem cell paradigm could offer not only fresh insight into sarcoma initiation and progression but also reveal new avenues for therapeutic interventions. Here we critically appraise the evidence for the presence of sarcoma stem cells in various pediatric sarcoma entities such as Rhabdomyosarcoma, Ewing sarcoma, Osteosarcoma, Undifferentiated Pleomorphic Sarcoma and Synovial sarcoma. The functional and molecular characterization of such stem cell-like cells has provided some hints as to the possible origins of sarcoma and it is likely that the sarcoma stem cell phenotype could be dependent on the sarcoma cell of origin and its genetic background. Finally the impact of sarcoma stem cell research in various aspects of patient care is explored. As of yet, the clinically relevant drugs targeting sarcoma stem cells have been sparse and their identification represents a clear need for further research." @default.
- W26754050 created "2016-06-24" @default.
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- W26754050 date "2013-09-12" @default.
- W26754050 modified "2023-09-23" @default.
- W26754050 title "Cancer Stem Cells in Pediatric Sarcomas" @default.
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- W26754050 doi "https://doi.org/10.1007/978-94-007-7329-5_10" @default.
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