Matches in SemOpenAlex for { <https://semopenalex.org/work/W2676083076> ?p ?o ?g. }
- W2676083076 abstract "Clinical management of esophageal adenocarcinoma (EAC) relies on radiation therapy, yet radioresistance is a pervasive challenge in this disease. The mechanisms of EAC radioresistance remain largely unknown due to a paucity of validated preclinical models. The present studies report on the development of seven primary xenograft models established from patient tumours. These models are used to interrogate the range of radiosensitivities and mechanisms of radioresistance in EAC tumours. We found that radiation enriches the tumour-initiating cell population in two xenograft lines tested. Furthermore, three tested xenograft lines respond to irradiation by upregulating Hedgehog transcripts, a pathway involved in stem cell maintenance and proliferation. Upregulation occurs in autocrine and paracrine patterns simultaneously, suggesting that Hedgehog signalling may have a complex role in the radioresponse of EAC tumours. These findings suggest that inhibiting stem cell pathways in combination with radiotherapy may have an important role in the clinical management of EAC.%%%%MAST" @default.
- W2676083076 created "2017-06-30" @default.
- W2676083076 creator A5062559348 @default.
- W2676083076 date "2012-11-27" @default.
- W2676083076 modified "2023-09-27" @default.
- W2676083076 title "Hedgehog Signalling and Tumour-initiating cells as Radioresistance Factors in Esophageal Adenocarcinoma" @default.
- W2676083076 cites W1527547321 @default.
- W2676083076 cites W1532026954 @default.
- W2676083076 cites W1542731069 @default.
- W2676083076 cites W1551102474 @default.
- W2676083076 cites W1607596367 @default.
- W2676083076 cites W1616179369 @default.
- W2676083076 cites W1826261498 @default.
- W2676083076 cites W1828227463 @default.
- W2676083076 cites W1885130542 @default.
- W2676083076 cites W1964010321 @default.
- W2676083076 cites W1966776119 @default.
- W2676083076 cites W1967304777 @default.
- W2676083076 cites W1969925021 @default.
- W2676083076 cites W197456213 @default.
- W2676083076 cites W1975275006 @default.
- W2676083076 cites W1976880272 @default.
- W2676083076 cites W1980809816 @default.
- W2676083076 cites W1982087641 @default.
- W2676083076 cites W1982603620 @default.
- W2676083076 cites W1988357840 @default.
- W2676083076 cites W1990944630 @default.
- W2676083076 cites W1992676863 @default.
- W2676083076 cites W1993815702 @default.
- W2676083076 cites W1994436445 @default.
- W2676083076 cites W1994459176 @default.
- W2676083076 cites W1994599132 @default.
- W2676083076 cites W1995820779 @default.
- W2676083076 cites W1997379399 @default.
- W2676083076 cites W1997445678 @default.
- W2676083076 cites W1997889647 @default.
- W2676083076 cites W1999316583 @default.
- W2676083076 cites W1999322281 @default.
- W2676083076 cites W1999960129 @default.
- W2676083076 cites W2001258296 @default.
- W2676083076 cites W2001663331 @default.
- W2676083076 cites W2005300609 @default.
- W2676083076 cites W2009811048 @default.
- W2676083076 cites W2009886857 @default.
- W2676083076 cites W2010547317 @default.
- W2676083076 cites W2010901031 @default.
- W2676083076 cites W2018671779 @default.
- W2676083076 cites W2019264784 @default.
- W2676083076 cites W2019395509 @default.
- W2676083076 cites W2019488062 @default.
- W2676083076 cites W2022904912 @default.
- W2676083076 cites W2023427658 @default.
- W2676083076 cites W2029231546 @default.
- W2676083076 cites W2030484446 @default.
- W2676083076 cites W2030575063 @default.
- W2676083076 cites W2033115042 @default.
- W2676083076 cites W2035341810 @default.
- W2676083076 cites W2037295429 @default.
- W2676083076 cites W2039058362 @default.
- W2676083076 cites W2043152231 @default.
- W2676083076 cites W2045956964 @default.
- W2676083076 cites W2047911328 @default.
- W2676083076 cites W2048233457 @default.
- W2676083076 cites W2050291003 @default.
- W2676083076 cites W2051148606 @default.
- W2676083076 cites W2052767351 @default.
- W2676083076 cites W2055078984 @default.
- W2676083076 cites W2055296003 @default.
- W2676083076 cites W2057435219 @default.
- W2676083076 cites W2057933081 @default.
- W2676083076 cites W2060524209 @default.
- W2676083076 cites W2060551076 @default.
- W2676083076 cites W2062118486 @default.
- W2676083076 cites W2062122187 @default.
- W2676083076 cites W2063307907 @default.
- W2676083076 cites W2066860206 @default.
- W2676083076 cites W2067535881 @default.
- W2676083076 cites W2067813478 @default.
- W2676083076 cites W2068219429 @default.
- W2676083076 cites W2074990506 @default.
- W2676083076 cites W2075890816 @default.
- W2676083076 cites W2079067257 @default.
- W2676083076 cites W2080508315 @default.
- W2676083076 cites W2082210456 @default.
- W2676083076 cites W2086152184 @default.
- W2676083076 cites W2090982381 @default.
- W2676083076 cites W2097308038 @default.
- W2676083076 cites W2097357142 @default.
- W2676083076 cites W2099879003 @default.
- W2676083076 cites W2100562940 @default.
- W2676083076 cites W2100929591 @default.
- W2676083076 cites W2107503279 @default.
- W2676083076 cites W2112725705 @default.
- W2676083076 cites W2115538252 @default.
- W2676083076 cites W2117223681 @default.
- W2676083076 cites W2118758371 @default.
- W2676083076 cites W2119037562 @default.
- W2676083076 cites W2120381403 @default.
- W2676083076 cites W2120608850 @default.
- W2676083076 cites W2120954784 @default.