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• W2676167845 abstract "Abstract Anaeroglobus geminatus is a relatively newly discovered putative pathogen, with a potential role in the microbial shift associated with periodontitis, a disease that causes inflammatory destruction of the periodontal tissues, and eventually tooth loss. This study aimed to introduce A. geminatus into a polymicrobial biofilm model of relevance to periodontitis, and monitor the proteomic responses exerted to the rest of the biofilm community. A. geminatus was grown together with another 10-species in a well-established “subgingival” in vitro biofilm model. Its effects on the other species were quantitatively evaluated by qPCR and label-free proteomics. A. geminatus caused a significant increase in P. intermedia numbers, but not the other species in the biofilm. Whole cell proteome profiling of the biofilms by LC-MS/MS identified a total of 3213 proteins. Label-free quantitative proteomics revealed that 187 proteins belonging to the other 10 species were differentially abundant when A. geminatus was present in the biofilm. The species with most up-regulated and down-regulated proteins were P. intermedia and S. oralis , respectively. Regulated proteins were of primarily of ribosomal origin, and other affected categories involved proteolysis, carbon metabolism and iron transport. In conclusion, A. geminatus can be successfully grown in a polymicrobial biofilm community, causing quantitative proteomic shifts commensurate with increased virulence properties." @default.
• W2676167845 created "2017-06-30" @default.
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• W2676167845 date "2017-06-30" @default.
• W2676167845 modified "2023-10-02" @default.
• W2676167845 title "Proteomic shifts in multi-species oral biofilms caused by Anaeroglobus geminatus" @default.
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• W2676167845 doi "https://doi.org/10.1038/s41598-017-04594-9" @default.
• W2676167845 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5493653" @default.
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