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- W267618195 abstract "Publisher Summary The in vitro inhibition of tumor growth (cytostasis) and tumor cytolysis (cytotoxicity) have been shown to be mediated by T cells, K cells, natural killer cells, and macrophages. Peritoneal exudate can be purified by adherence directly onto the microtest plates before adding the target tumor cells. A major problem in the cytostasis assay is in intrepreting the data and avoiding the numerous artifacts that either directly or indirectly alter cell growth and, while causing the appearance of cytostasis in the in vitro environment, are unlikely to be relevant in vivo. Another problem frequently overlooked in evaluating cytostasis experiments is the potential cytotoxicity of the effector cells. Cytostasis can be detected earlier after the initiation of cultures than cytotoxicity; however, it is not known that whether or not cytostasis is a prerequisite for cytotoxicity, it shares a common mechanism with cytotoxicity, or is irrelevant to cytotoxicity. Perhaps the ideal target cell for cytostasis assays would be a tumor cell that is resistant to the cytotoxic effects of macrophages or any other effector cell in question; however, it is not clear that such a tumor target cell exists." @default.
- W267618195 created "2016-06-24" @default.
- W267618195 creator A5083144327 @default.
- W267618195 date "1981-01-01" @default.
- W267618195 modified "2023-09-25" @default.
- W267618195 title "CYTOSTASIS OF TUMOR AND NONTUMOR CELLS" @default.
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- W267618195 doi "https://doi.org/10.1016/b978-0-12-044220-1.50080-5" @default.
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