Matches in SemOpenAlex for { <https://semopenalex.org/work/W2678050369> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W2678050369 abstract "Sigma receptors have become a popular subject for research the past few decades, but there is still much mystery behind these receptors and how they work. Sigma receptors, like cannabinoid-1 (CB1) receptors, have effects on the human body including appetite regulation, depression, and analgesia. AZ66 is a highly selective sigma receptor ligand that has antagonistic properties. Sigma receptor antagonists have been shown to potentiate the analgesic effects of opiates; however, there are no known literature reports about the interaction between the sigma receptor system and the endocannabinoid system, including CB1 receptors. The purpose of this study is to evaluate AZ66 for potentiation of CB1 related analgesic effects. A tetrad assay was performed for AZ66 using doses 5, 10, and 20 mg/kg (i.p.). The tetrad battery was performed one hour post drug (AZ66) administration. The potentiation study was completed using a 20 mg/kg dose of AZ66 against a 0.3 mg/kg dose of CP 55940. The AZ66 dose was administered one hour before the CP 55940 dose administration, and then the analgesic study was performed 15 minutes post CP 55940 dose administration. The tetrad assay showed that AZ66 exhibited no analgesic effects on its own compared to the control compounds. The potentiation study resulted in significant potentiation of the peripheral analgesic effects of CP 55940 with the addition of AZ66 and insignificant potentiation of central analgesic effects. Future studies will be performed to validate the findings of this study and to further examine the interaction between the sigma receptor system and the cannabinoid system. �" @default.
- W2678050369 created "2017-06-30" @default.
- W2678050369 creator A5079592600 @default.
- W2678050369 date "2017-01-01" @default.
- W2678050369 modified "2023-09-24" @default.
- W2678050369 title "Evaluation of Sigma Ligand AZ66 Analgesic Potentiation of Cannabinoids" @default.
- W2678050369 cites W1565858669 @default.
- W2678050369 cites W1695278265 @default.
- W2678050369 cites W1897302826 @default.
- W2678050369 cites W2034509002 @default.
- W2678050369 cites W2138295551 @default.
- W2678050369 cites W629902553 @default.
- W2678050369 cites W641319889 @default.
- W2678050369 hasPublicationYear "2017" @default.
- W2678050369 type Work @default.
- W2678050369 sameAs 2678050369 @default.
- W2678050369 citedByCount "0" @default.
- W2678050369 crossrefType "dissertation" @default.
- W2678050369 hasAuthorship W2678050369A5079592600 @default.
- W2678050369 hasConcept C126322002 @default.
- W2678050369 hasConcept C148001335 @default.
- W2678050369 hasConcept C170493617 @default.
- W2678050369 hasConcept C185592680 @default.
- W2678050369 hasConcept C25274449 @default.
- W2678050369 hasConcept C2778938600 @default.
- W2678050369 hasConcept C2780820201 @default.
- W2678050369 hasConcept C2780871563 @default.
- W2678050369 hasConcept C46721173 @default.
- W2678050369 hasConcept C71924100 @default.
- W2678050369 hasConcept C98274493 @default.
- W2678050369 hasConceptScore W2678050369C126322002 @default.
- W2678050369 hasConceptScore W2678050369C148001335 @default.
- W2678050369 hasConceptScore W2678050369C170493617 @default.
- W2678050369 hasConceptScore W2678050369C185592680 @default.
- W2678050369 hasConceptScore W2678050369C25274449 @default.
- W2678050369 hasConceptScore W2678050369C2778938600 @default.
- W2678050369 hasConceptScore W2678050369C2780820201 @default.
- W2678050369 hasConceptScore W2678050369C2780871563 @default.
- W2678050369 hasConceptScore W2678050369C46721173 @default.
- W2678050369 hasConceptScore W2678050369C71924100 @default.
- W2678050369 hasConceptScore W2678050369C98274493 @default.
- W2678050369 hasLocation W26780503691 @default.
- W2678050369 hasOpenAccess W2678050369 @default.
- W2678050369 hasPrimaryLocation W26780503691 @default.
- W2678050369 hasRelatedWork W1510752544 @default.
- W2678050369 hasRelatedWork W1976033325 @default.
- W2678050369 hasRelatedWork W1983128722 @default.
- W2678050369 hasRelatedWork W2011204298 @default.
- W2678050369 hasRelatedWork W2020595514 @default.
- W2678050369 hasRelatedWork W2053224661 @default.
- W2678050369 hasRelatedWork W2065570495 @default.
- W2678050369 hasRelatedWork W2070546471 @default.
- W2678050369 hasRelatedWork W2095029167 @default.
- W2678050369 hasRelatedWork W2113456510 @default.
- W2678050369 hasRelatedWork W2147361549 @default.
- W2678050369 hasRelatedWork W2164953364 @default.
- W2678050369 hasRelatedWork W2174069020 @default.
- W2678050369 hasRelatedWork W2271526865 @default.
- W2678050369 hasRelatedWork W2277069926 @default.
- W2678050369 hasRelatedWork W2330108353 @default.
- W2678050369 hasRelatedWork W2618447839 @default.
- W2678050369 hasRelatedWork W2951156176 @default.
- W2678050369 hasRelatedWork W2963071407 @default.
- W2678050369 hasRelatedWork W3118353220 @default.
- W2678050369 isParatext "false" @default.
- W2678050369 isRetracted "false" @default.
- W2678050369 magId "2678050369" @default.
- W2678050369 workType "dissertation" @default.