Matches in SemOpenAlex for { <https://semopenalex.org/work/W2678124820> ?p ?o ?g. }
- W2678124820 endingPage "1690" @default.
- W2678124820 startingPage "1685" @default.
- W2678124820 abstract "It has previously been demonstrated that glucose is important in the process of stem cell aging. However, the mechanisms of cell senescence induced by high glucose (HG) remain to be elucidated. The preliminary study indicated that D‑galactose induced mesenchymal stem cell (MSCs) aging. The present study demonstrated, following treatment with 11.0 or 22.0 mM HG for 14 days, that HG significantly promoted MSCs aging and the expression levels of phosphorylated (p-)phosphatidylinositol 3-kinase/protein kinase B (Akt) and p‑mammalian target of rapamycin signaling (mTOR) in the HG groups were increased compared with the control group. However, following Akt inhibition with 1.0 or 10.0 nM MK‑2206, which is an Akt‑specific small molecule inhibitor, the senescence‑cell value in the HG group was significantly decreased compared with the control group. These results indicated that HG induced MSCs senescence and this effect was primarily mediated via the Akt/mTOR signaling pathway." @default.
- W2678124820 created "2017-06-30" @default.
- W2678124820 creator A5000453901 @default.
- W2678124820 creator A5002032950 @default.
- W2678124820 creator A5047835985 @default.
- W2678124820 creator A5051256710 @default.
- W2678124820 creator A5051926582 @default.
- W2678124820 creator A5063457618 @default.
- W2678124820 creator A5064598398 @default.
- W2678124820 creator A5064987530 @default.
- W2678124820 creator A5065163800 @default.
- W2678124820 creator A5070838341 @default.
- W2678124820 creator A5075972902 @default.
- W2678124820 creator A5090788014 @default.
- W2678124820 date "2017-02-01" @default.
- W2678124820 modified "2023-10-13" @default.
- W2678124820 title "High glucose induces the aging of mesenchymal stem cells via Akt/mTOR signaling" @default.
- W2678124820 cites W1491914731 @default.
- W2678124820 cites W1527969433 @default.
- W2678124820 cites W1605422985 @default.
- W2678124820 cites W1774279657 @default.
- W2678124820 cites W1952784257 @default.
- W2678124820 cites W1969281194 @default.
- W2678124820 cites W1974033361 @default.
- W2678124820 cites W1998671183 @default.
- W2678124820 cites W2021139735 @default.
- W2678124820 cites W2021474483 @default.
- W2678124820 cites W2022322309 @default.
- W2678124820 cites W2023538191 @default.
- W2678124820 cites W2041386692 @default.
- W2678124820 cites W2042685144 @default.
- W2678124820 cites W2048992180 @default.
- W2678124820 cites W2051298035 @default.
- W2678124820 cites W2053092860 @default.
- W2678124820 cites W2059807701 @default.
- W2678124820 cites W2075734310 @default.
- W2678124820 cites W2086655045 @default.
- W2678124820 cites W2098029600 @default.
- W2678124820 cites W2098459519 @default.
- W2678124820 cites W2108881298 @default.
- W2678124820 cites W2109776466 @default.
- W2678124820 cites W2114156291 @default.
- W2678124820 cites W2121431403 @default.
- W2678124820 cites W2133967407 @default.
- W2678124820 cites W2159701110 @default.
- W2678124820 cites W2164671411 @default.
- W2678124820 cites W2172517621 @default.
- W2678124820 cites W2187531586 @default.
- W2678124820 cites W2189537773 @default.
- W2678124820 cites W2203178461 @default.
- W2678124820 cites W2261880761 @default.
- W2678124820 cites W2267416951 @default.
- W2678124820 cites W2282635561 @default.
- W2678124820 cites W2286971754 @default.
- W2678124820 cites W2301151326 @default.
- W2678124820 cites W2401538206 @default.
- W2678124820 cites W276702877 @default.
- W2678124820 cites W967994874 @default.
- W2678124820 doi "https://doi.org/10.3892/mmr.2017.6832" @default.
- W2678124820 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5562095" @default.
- W2678124820 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28656269" @default.
- W2678124820 hasPublicationYear "2017" @default.
- W2678124820 type Work @default.
- W2678124820 sameAs 2678124820 @default.
- W2678124820 citedByCount "42" @default.
- W2678124820 countsByYear W26781248202017 @default.
- W2678124820 countsByYear W26781248202018 @default.
- W2678124820 countsByYear W26781248202019 @default.
- W2678124820 countsByYear W26781248202020 @default.
- W2678124820 countsByYear W26781248202021 @default.
- W2678124820 countsByYear W26781248202022 @default.
- W2678124820 countsByYear W26781248202023 @default.
- W2678124820 crossrefType "journal-article" @default.
- W2678124820 hasAuthorship W2678124820A5000453901 @default.
- W2678124820 hasAuthorship W2678124820A5002032950 @default.
- W2678124820 hasAuthorship W2678124820A5047835985 @default.
- W2678124820 hasAuthorship W2678124820A5051256710 @default.
- W2678124820 hasAuthorship W2678124820A5051926582 @default.
- W2678124820 hasAuthorship W2678124820A5063457618 @default.
- W2678124820 hasAuthorship W2678124820A5064598398 @default.
- W2678124820 hasAuthorship W2678124820A5064987530 @default.
- W2678124820 hasAuthorship W2678124820A5065163800 @default.
- W2678124820 hasAuthorship W2678124820A5070838341 @default.
- W2678124820 hasAuthorship W2678124820A5075972902 @default.
- W2678124820 hasAuthorship W2678124820A5090788014 @default.
- W2678124820 hasBestOaLocation W26781248201 @default.
- W2678124820 hasConcept C11960822 @default.
- W2678124820 hasConcept C1491633281 @default.
- W2678124820 hasConcept C184235292 @default.
- W2678124820 hasConcept C185592680 @default.
- W2678124820 hasConcept C198826908 @default.
- W2678124820 hasConcept C2780610907 @default.
- W2678124820 hasConcept C2781018059 @default.
- W2678124820 hasConcept C28328180 @default.
- W2678124820 hasConcept C29537977 @default.
- W2678124820 hasConcept C502942594 @default.
- W2678124820 hasConcept C522857546 @default.
- W2678124820 hasConcept C55493867 @default.