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• W267879079 abstract "Research Article1 August 1993free access Vps1p, a member of the dynamin GTPase family, is necessary for Golgi membrane protein retention in Saccharomyces cerevisiae. K. Wilsbach K. Wilsbach Molecular Biology Institute, University of California, Los Angeles 90024. Search for more papers by this author G.S. Payne G.S. Payne Molecular Biology Institute, University of California, Los Angeles 90024. Search for more papers by this author K. Wilsbach K. Wilsbach Molecular Biology Institute, University of California, Los Angeles 90024. Search for more papers by this author G.S. Payne G.S. Payne Molecular Biology Institute, University of California, Los Angeles 90024. Search for more papers by this author Author Information K. Wilsbach1 and G.S. Payne1 1Molecular Biology Institute, University of California, Los Angeles 90024. The EMBO Journal (1993)12:3049-3059https://doi.org/10.1002/j.1460-2075.1993.tb05974.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info The KEX2-encoded endoprotease of Saccharomyces cerevisiae resides in the Golgi complex where it participates in the maturation of alpha-factor mating pheromone precursor. Clathrin heavy chain gene disruptions cause mislocalization of Kex2p to the cell surface and reduce maturation of the alpha-factor precursor. Based on these findings, a genetic screen has been devised to isolate mutations that affect retention of Kex2p in the Golgi complex. Two alleles of a single genetic locus, lam1 (lowered alpha-factor maturation), have been isolated, which result in inefficient maturation of alpha-factor precursor. In lam1 cells, Kex2p is not mislocalized to the cell surface but is abnormally unstable. Normal stability is restored by the pep4 mutation which reduces the activity of vacuolar proteases. In contrast, the pheromone maturation defect is not corrected by pep4. Organelle fractionation by sucrose density gradient centrifugation shows that Kex2p is not retained in the Golgi complex of lam1 cells. Vacuolar protein precursors are secreted by lam1 mutants, revealing another sorting defect in the Golgi complex. Genetic complementation reveals that lam1 is allelic to the VPS1 gene, which encodes a dynamin-related GTPase. These results indicate that Vps1p is necessary for membrane protein retention in a late Golgi compartment. Previous ArticleNext Article Volume 12Issue 81 August 1993In this issue RelatedDetailsLoading ..." @default.
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• W267879079 date "1993-08-01" @default.
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• W267879079 title "Vps1p, a member of the dynamin GTPase family, is necessary for Golgi membrane protein retention in Saccharomyces cerevisiae." @default.
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• W267879079 doi "https://doi.org/10.1002/j.1460-2075.1993.tb05974.x" @default.
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