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- W267918074 abstract "In patients in a surgical intensive care unit a controlled clinical trial was performed concerned with the pathophysiological functions of histamine in stress ulcer disease and with the influence of cimetidine prophylaxis on this complication. The commonly used organization of a controlled clinical trial was enforced to be changed by considerable theoretical, ethical and practical difficulties in designing and conducting the study: As a surprising and remarkable result of the study clinically manifest stress ulcers occurred exclusively in our patients in the intensive care unit and among them mainly in those with severy polytrauma and postoperative complications. Cimetidine was highly effective in preventing stress ulceration in severe polytrauma patients. But it seems absolutely unnecessary to distribute this drug in all patients of a surgical intensive care unit like from a cornucopia of happiness." @default.
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- W267918074 date "1980-07-01" @default.
- W267918074 modified "2023-09-26" @default.
- W267918074 title "Histamine and stress ulcer: New components in organizing a sequential trial on cimetidine prophylaxis in seriously Ill patients and definition of a special group at risk (severe polytrauma)" @default.
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- W267918074 doi "https://doi.org/10.1007/bf01478603" @default.
- W267918074 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7442079" @default.
- W267918074 hasPublicationYear "1980" @default.
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