Matches in SemOpenAlex for { <https://semopenalex.org/work/W2679259315> ?p ?o ?g. }
- W2679259315 endingPage "1749" @default.
- W2679259315 startingPage "1739" @default.
- W2679259315 abstract "The blockade of inhibitory receptors such as CTLA-4 (CD152) is being used as immune-checkpoint therapy, offering a powerful strategy to restore effective immune responses against tumors. To determine signal components that are induced under the control of CTLA-4 we analyzed activated murine CD8+ T cells by quantitative proteomics. Accurate mass spectrometry revealed that CTLA-4 engagement led to central changes in the phosphorylation of proteins involved in T-cell differentiation. Beside other targets, we discovered a CTLA-4-mediated induction of the translational inhibitor programmed cell death-4 (PDCD4) as a result of FoxO1 nuclear re-localization. PDCD4 further bound a distinct set of mRNAs including Glutaminase, which points out a critical role for CTLA-4 in CD8+ T-cell metabolism. Consequently, PDCD4-deficient cytotoxic T-lymphocytes (CTLs) expressed increased amounts of otherwise repressed effector molecules and ultimately led to superior control of tumor growth in vivo. These findings reveal a novel CTLA-4-mediated pathway to attenuate CTLs and indicate the importance of post-transcriptional mechanisms in the regulation of anti-tumor immune responses." @default.
- W2679259315 created "2017-06-30" @default.
- W2679259315 creator A5011611465 @default.
- W2679259315 creator A5017775954 @default.
- W2679259315 creator A5019664227 @default.
- W2679259315 creator A5022062058 @default.
- W2679259315 creator A5031338205 @default.
- W2679259315 creator A5046891162 @default.
- W2679259315 creator A5049605606 @default.
- W2679259315 creator A5058720268 @default.
- W2679259315 creator A5076995639 @default.
- W2679259315 creator A5088547780 @default.
- W2679259315 date "2017-06-23" @default.
- W2679259315 modified "2023-10-15" @default.
- W2679259315 title "CTLA-4-mediated posttranslational modifications direct cytotoxic T-lymphocyte differentiation" @default.
- W2679259315 cites W1482928030 @default.
- W2679259315 cites W1507800008 @default.
- W2679259315 cites W1642873092 @default.
- W2679259315 cites W1825402033 @default.
- W2679259315 cites W1906040944 @default.
- W2679259315 cites W1945715178 @default.
- W2679259315 cites W1965598882 @default.
- W2679259315 cites W1966644185 @default.
- W2679259315 cites W1970111367 @default.
- W2679259315 cites W1975627280 @default.
- W2679259315 cites W1975797839 @default.
- W2679259315 cites W1979147887 @default.
- W2679259315 cites W1980417017 @default.
- W2679259315 cites W1992581811 @default.
- W2679259315 cites W2013043293 @default.
- W2679259315 cites W2015415347 @default.
- W2679259315 cites W2015587858 @default.
- W2679259315 cites W2021340905 @default.
- W2679259315 cites W2029855686 @default.
- W2679259315 cites W2030375564 @default.
- W2679259315 cites W2037623985 @default.
- W2679259315 cites W203838027 @default.
- W2679259315 cites W2043274355 @default.
- W2679259315 cites W2044960186 @default.
- W2679259315 cites W2048073154 @default.
- W2679259315 cites W2053725511 @default.
- W2679259315 cites W2056100438 @default.
- W2679259315 cites W2060910588 @default.
- W2679259315 cites W2063261544 @default.
- W2679259315 cites W2070820426 @default.
- W2679259315 cites W2073179024 @default.
- W2679259315 cites W2079999658 @default.
- W2679259315 cites W2080442133 @default.
- W2679259315 cites W2094366129 @default.
- W2679259315 cites W2103228630 @default.
- W2679259315 cites W2104052951 @default.
- W2679259315 cites W2106419549 @default.
- W2679259315 cites W2108002172 @default.
- W2679259315 cites W2112601576 @default.
- W2679259315 cites W2115619054 @default.
- W2679259315 cites W2116086384 @default.
- W2679259315 cites W2118054479 @default.
- W2679259315 cites W2120568877 @default.
- W2679259315 cites W2128440308 @default.
- W2679259315 cites W2130132119 @default.
- W2679259315 cites W2134638467 @default.
- W2679259315 cites W2136808297 @default.
- W2679259315 cites W2158724645 @default.
- W2679259315 cites W2160322856 @default.
- W2679259315 cites W2162856391 @default.
- W2679259315 cites W2165439432 @default.
- W2679259315 cites W2406555542 @default.
- W2679259315 cites W2592935721 @default.
- W2679259315 cites W4251765607 @default.
- W2679259315 doi "https://doi.org/10.1038/cdd.2017.102" @default.
- W2679259315 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5596418" @default.
- W2679259315 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28644433" @default.
- W2679259315 hasPublicationYear "2017" @default.
- W2679259315 type Work @default.
- W2679259315 sameAs 2679259315 @default.
- W2679259315 citedByCount "29" @default.
- W2679259315 countsByYear W26792593152018 @default.
- W2679259315 countsByYear W26792593152019 @default.
- W2679259315 countsByYear W26792593152020 @default.
- W2679259315 countsByYear W26792593152021 @default.
- W2679259315 countsByYear W26792593152022 @default.
- W2679259315 countsByYear W26792593152023 @default.
- W2679259315 crossrefType "journal-article" @default.
- W2679259315 hasAuthorship W2679259315A5011611465 @default.
- W2679259315 hasAuthorship W2679259315A5017775954 @default.
- W2679259315 hasAuthorship W2679259315A5019664227 @default.
- W2679259315 hasAuthorship W2679259315A5022062058 @default.
- W2679259315 hasAuthorship W2679259315A5031338205 @default.
- W2679259315 hasAuthorship W2679259315A5046891162 @default.
- W2679259315 hasAuthorship W2679259315A5049605606 @default.
- W2679259315 hasAuthorship W2679259315A5058720268 @default.
- W2679259315 hasAuthorship W2679259315A5076995639 @default.
- W2679259315 hasAuthorship W2679259315A5088547780 @default.
- W2679259315 hasBestOaLocation W26792593151 @default.
- W2679259315 hasConcept C120642132 @default.
- W2679259315 hasConcept C154317977 @default.
- W2679259315 hasConcept C167672396 @default.
- W2679259315 hasConcept C185592680 @default.