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- W26793886 abstract "Rapid advances in our understanding of radiation responses, at the subcellular, cellular, tissue and whole body levels have been driven by the advent of new technological approaches for radiation delivery. Ionising radiation microbeams allow precise doses of radiation to be delivered with high spatial accuracy. They have evolved through recent advances in imaging, software and beam delivery to be used in a range of experimental studies probing spatial, temporal and low dose aspects of radiation response. A range of microbeams have been developed worldwide which include ones capable of delivering charged particles, X-rays and electrons. The original rational for their development was as a precise means of measuring the effects of single radiation tracks. However, the ability to target radiation with microbeams at subcellular targets has been used to address fundamental questions related to radiosensitive sites within cells. Further developments include using microbeams to target more complex 3-D systems where the possibilities of utilizing the unique characteristics of microbeams in terms of their spatial and temporal delivery will make a major impact.KeywordsUrothelial CellRadiation ResponseRadiation MicrobeamBystander ResponseBystander SignallingThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves." @default.
- W26793886 created "2016-06-24" @default.
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- W26793886 date "2011-11-30" @default.
- W26793886 modified "2023-09-23" @default.
- W26793886 title "Spatial and Temporal Aspects of Radiation Response in Cell and Tissue Models" @default.
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- W26793886 doi "https://doi.org/10.1007/978-94-007-2564-5_23" @default.
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