Matches in SemOpenAlex for { <https://semopenalex.org/work/W2679663788> ?p ?o ?g. }
- W2679663788 abstract "Myelin basic protein (MBP) is a key component of myelin, the specialized lipid membrane that encases the axons of all neurons. Both plasminogen (Pg) and tissue-type plasminogen activator (t-PA) bind to MBP with high affinity. We investigated the kinetics and mechanisms involved in this process using immobilized MBP and found that Pg activation by t-PA is significantly stimulated by MBP. This mechanism involves the binding of t-PA via a lysine-dependent mechanism to the Lys91 residue of the MBP NH2-terminal region Asp82 -Pro99, and the binding of Pg via a lysine-dependent mechanism to the Lys122 residue of the MBP COOH-terminal region Leu109-Gly126. In this context, MBP mimics fibrin and because MBP is a plasmin substrate, our results suggest direct participation of the Pg activation system on MBP physiology." @default.
- W2679663788 created "2017-06-30" @default.
- W2679663788 creator A5002661071 @default.
- W2679663788 creator A5019176945 @default.
- W2679663788 creator A5033044191 @default.
- W2679663788 creator A5054901336 @default.
- W2679663788 creator A5058385022 @default.
- W2679663788 creator A5059431609 @default.
- W2679663788 creator A5090928660 @default.
- W2679663788 date "2017-08-01" @default.
- W2679663788 modified "2023-10-02" @default.
- W2679663788 title "Myelin basic protein stimulates plasminogen activation via tissue plasminogen activator following binding to independent l -lysine-containing domains" @default.
- W2679663788 cites W1494500191 @default.
- W2679663788 cites W1586576093 @default.
- W2679663788 cites W1590159040 @default.
- W2679663788 cites W1969834563 @default.
- W2679663788 cites W1981989118 @default.
- W2679663788 cites W1983277257 @default.
- W2679663788 cites W1983556223 @default.
- W2679663788 cites W1995619379 @default.
- W2679663788 cites W2003621176 @default.
- W2679663788 cites W2013860583 @default.
- W2679663788 cites W2014696861 @default.
- W2679663788 cites W2014705302 @default.
- W2679663788 cites W2022365383 @default.
- W2679663788 cites W2024821974 @default.
- W2679663788 cites W2032728373 @default.
- W2679663788 cites W2039405454 @default.
- W2679663788 cites W2047899819 @default.
- W2679663788 cites W2067258308 @default.
- W2679663788 cites W2067927805 @default.
- W2679663788 cites W2072079501 @default.
- W2679663788 cites W2086386772 @default.
- W2679663788 cites W2091313087 @default.
- W2679663788 cites W2092633684 @default.
- W2679663788 cites W2100837269 @default.
- W2679663788 cites W2101108802 @default.
- W2679663788 cites W2106241842 @default.
- W2679663788 cites W2121277900 @default.
- W2679663788 cites W2126563037 @default.
- W2679663788 cites W2133045741 @default.
- W2679663788 cites W2142925852 @default.
- W2679663788 cites W2149194357 @default.
- W2679663788 cites W2159762359 @default.
- W2679663788 cites W2590805155 @default.
- W2679663788 cites W2759735155 @default.
- W2679663788 cites W2183244382 @default.
- W2679663788 doi "https://doi.org/10.1016/j.bbrc.2017.06.131" @default.
- W2679663788 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28648598" @default.
- W2679663788 hasPublicationYear "2017" @default.
- W2679663788 type Work @default.
- W2679663788 sameAs 2679663788 @default.
- W2679663788 citedByCount "0" @default.
- W2679663788 crossrefType "journal-article" @default.
- W2679663788 hasAuthorship W2679663788A5002661071 @default.
- W2679663788 hasAuthorship W2679663788A5019176945 @default.
- W2679663788 hasAuthorship W2679663788A5033044191 @default.
- W2679663788 hasAuthorship W2679663788A5054901336 @default.
- W2679663788 hasAuthorship W2679663788A5058385022 @default.
- W2679663788 hasAuthorship W2679663788A5059431609 @default.
- W2679663788 hasAuthorship W2679663788A5090928660 @default.
- W2679663788 hasConcept C134018914 @default.
- W2679663788 hasConcept C153911025 @default.
- W2679663788 hasConcept C181199279 @default.
- W2679663788 hasConcept C185592680 @default.
- W2679663788 hasConcept C2776016237 @default.
- W2679663788 hasConcept C2776572282 @default.
- W2679663788 hasConcept C2778609137 @default.
- W2679663788 hasConcept C2779679481 @default.
- W2679663788 hasConcept C2780876595 @default.
- W2679663788 hasConcept C2781071845 @default.
- W2679663788 hasConcept C515207424 @default.
- W2679663788 hasConcept C529278444 @default.
- W2679663788 hasConcept C55493867 @default.
- W2679663788 hasConcept C86803240 @default.
- W2679663788 hasConcept C95444343 @default.
- W2679663788 hasConceptScore W2679663788C134018914 @default.
- W2679663788 hasConceptScore W2679663788C153911025 @default.
- W2679663788 hasConceptScore W2679663788C181199279 @default.
- W2679663788 hasConceptScore W2679663788C185592680 @default.
- W2679663788 hasConceptScore W2679663788C2776016237 @default.
- W2679663788 hasConceptScore W2679663788C2776572282 @default.
- W2679663788 hasConceptScore W2679663788C2778609137 @default.
- W2679663788 hasConceptScore W2679663788C2779679481 @default.
- W2679663788 hasConceptScore W2679663788C2780876595 @default.
- W2679663788 hasConceptScore W2679663788C2781071845 @default.
- W2679663788 hasConceptScore W2679663788C515207424 @default.
- W2679663788 hasConceptScore W2679663788C529278444 @default.
- W2679663788 hasConceptScore W2679663788C55493867 @default.
- W2679663788 hasConceptScore W2679663788C86803240 @default.
- W2679663788 hasConceptScore W2679663788C95444343 @default.
- W2679663788 hasFunder F4320338073 @default.
- W2679663788 hasLocation W26796637881 @default.
- W2679663788 hasLocation W26796637882 @default.
- W2679663788 hasOpenAccess W2679663788 @default.
- W2679663788 hasPrimaryLocation W26796637881 @default.
- W2679663788 hasRelatedWork W146606962 @default.
- W2679663788 hasRelatedWork W1986234408 @default.
- W2679663788 hasRelatedWork W1989204626 @default.
- W2679663788 hasRelatedWork W2026633066 @default.