FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2679873033> ?p ?o ?g. }

• W2679873033 endingPage "47" @default.
• W2679873033 startingPage "39" @default.
• W2679873033 abstract "Acute exposure to stress induces significant behavioural changes, while repeated exposure to the same stressor leads to the development of tolerance to stress. The development of tolerance appears to involve the serotonergic projections from the Median Raphe Nucleus (MnRN) to the dorsal Hippocampus (dH), since rats with lesions of this pathway does not develop tolerance to stress. Previous data from our laboratory showed that treatment with imipramine, a serotonin (5-HT) and noradrenaline (NA) reuptake inhibitor, lead to the development of tolerance. However, it remains to be elucidated whether such tolerance involves the participation of the noradrenergic system, apart from the serotonergic projections. Therefore, the aim of this work was to investigate the behavioural and neurochemical effects of chronic treatment with desipramine (NA reuptake inhibitor) or fluoxetine (5-HT reuptake inhibitor) in chronically stressed rats with lesions of the serotonergic neurons of the MnRN. Male Wistar rats with or without lesion in the MnRN were submitted or not to acute (2 h) or chronic restraint (2 h/seven days) stress and tested in the elevated pus maze (EPM). Treatment with fluoxetine, desipramine (10 mg/kg) or saline was performed twice daily (12-12 h interval), for 7 consecutive days. EPM test was conducted 24 h after the treatment. Fluoxetine attenuated the anxiogenic-induced effect of lesion in chronically restrained rats, without changing serotonin and noradrenaline levels in the hippocampus of lesioned rats. A similar profile was also observed after treatment with desipramine. These results suggest that both the serotonergic and the noradrenergic systems are involved in the development of tolerance to chronic stress. Additionally, the integrity of the serotonergic pathway of the MnRN-dH is not essential for the anxiolytic-like effects of these drugs." @default.
• W2679873033 created "2017-06-30" @default.
• W2679873033 creator A5002890129 @default.
• W2679873033 creator A5012001005 @default.
• W2679873033 creator A5016359706 @default.
• W2679873033 date "2019-01-01" @default.
• W2679873033 modified "2023-09-27" @default.
• W2679873033 title "Both serotonergic and noradrenergic systems modulate the development of tolerance to chronic stress in rats with lesions of the serotonergic neurons of the median raphe nucleus" @default.
• W2679873033 cites W1967421959 @default.
• W2679873033 cites W1967913887 @default.
• W2679873033 cites W1968929764 @default.
• W2679873033 cites W1969750389 @default.
• W2679873033 cites W1978940913 @default.
• W2679873033 cites W1987906603 @default.
• W2679873033 cites W1994121585 @default.
• W2679873033 cites W2000040230 @default.
• W2679873033 cites W2003686526 @default.
• W2679873033 cites W2014752704 @default.
• W2679873033 cites W2016336988 @default.
• W2679873033 cites W2023414423 @default.
• W2679873033 cites W2031001813 @default.
• W2679873033 cites W2035266273 @default.
• W2679873033 cites W2038665328 @default.
• W2679873033 cites W2043636380 @default.
• W2679873033 cites W2052318755 @default.
• W2679873033 cites W2056575770 @default.
• W2679873033 cites W2057374306 @default.
• W2679873033 cites W2061929866 @default.
• W2679873033 cites W2089299823 @default.
• W2679873033 cites W2091064555 @default.
• W2679873033 cites W2095133221 @default.
• W2679873033 cites W2108265430 @default.
• W2679873033 cites W2137950391 @default.
• W2679873033 cites W2142845741 @default.
• W2679873033 cites W2147289447 @default.
• W2679873033 cites W2154760725 @default.
• W2679873033 cites W2158178761 @default.
• W2679873033 cites W2161054906 @default.
• W2679873033 cites W2170165650 @default.
• W2679873033 cites W2170226754 @default.
• W2679873033 cites W2233054097 @default.
• W2679873033 doi "https://doi.org/10.1016/j.bbr.2017.06.037" @default.
• W2679873033 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28662893" @default.
• W2679873033 hasPublicationYear "2019" @default.
• W2679873033 type Work @default.
• W2679873033 sameAs 2679873033 @default.
• W2679873033 citedByCount "6" @default.
• W2679873033 countsByYear W26798730332019 @default.
• W2679873033 countsByYear W26798730332020 @default.
• W2679873033 countsByYear W26798730332021 @default.
• W2679873033 countsByYear W26798730332022 @default.
• W2679873033 crossrefType "journal-article" @default.
• W2679873033 hasAuthorship W2679873033A5002890129 @default.
• W2679873033 hasAuthorship W2679873033A5012001005 @default.
• W2679873033 hasAuthorship W2679873033A5016359706 @default.
• W2679873033 hasConcept C126322002 @default.
• W2679873033 hasConcept C134018914 @default.
• W2679873033 hasConcept C142724271 @default.
• W2679873033 hasConcept C15744967 @default.
• W2679873033 hasConcept C170493617 @default.
• W2679873033 hasConcept C204787440 @default.
• W2679873033 hasConcept C25876315 @default.
• W2679873033 hasConcept C2775864247 @default.
• W2679873033 hasConcept C2776134451 @default.
• W2679873033 hasConcept C2776570665 @default.
• W2679873033 hasConcept C2777865548 @default.
• W2679873033 hasConcept C2779145073 @default.
• W2679873033 hasConcept C2779177272 @default.
• W2679873033 hasConcept C2780092697 @default.
• W2679873033 hasConcept C2780250439 @default.
• W2679873033 hasConcept C2780997500 @default.
• W2679873033 hasConcept C2781161787 @default.
• W2679873033 hasConcept C31487548 @default.
• W2679873033 hasConcept C32610206 @default.
• W2679873033 hasConcept C37000724 @default.
• W2679873033 hasConcept C71924100 @default.
• W2679873033 hasConcept C99631742 @default.
• W2679873033 hasConceptScore W2679873033C126322002 @default.
• W2679873033 hasConceptScore W2679873033C134018914 @default.
• W2679873033 hasConceptScore W2679873033C142724271 @default.
• W2679873033 hasConceptScore W2679873033C15744967 @default.
• W2679873033 hasConceptScore W2679873033C170493617 @default.
• W2679873033 hasConceptScore W2679873033C204787440 @default.
• W2679873033 hasConceptScore W2679873033C25876315 @default.
• W2679873033 hasConceptScore W2679873033C2775864247 @default.
• W2679873033 hasConceptScore W2679873033C2776134451 @default.
• W2679873033 hasConceptScore W2679873033C2776570665 @default.
• W2679873033 hasConceptScore W2679873033C2777865548 @default.
• W2679873033 hasConceptScore W2679873033C2779145073 @default.
• W2679873033 hasConceptScore W2679873033C2779177272 @default.
• W2679873033 hasConceptScore W2679873033C2780092697 @default.
• W2679873033 hasConceptScore W2679873033C2780250439 @default.
• W2679873033 hasConceptScore W2679873033C2780997500 @default.
• W2679873033 hasConceptScore W2679873033C2781161787 @default.
• W2679873033 hasConceptScore W2679873033C31487548 @default.
• W2679873033 hasConceptScore W2679873033C32610206 @default.
• W2679873033 hasConceptScore W2679873033C37000724 @default.
• W2679873033 hasConceptScore W2679873033C71924100 @default.

• next