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- W26855876 abstract "Radiofrequency ablation (RFA) is an established procedure for therapy of tumors of parenchymatous organs like the liver. RFA could also be suitable for the minimally invasive therapy of singular thyroid nodules. The aim of this study was to establish a dose-response relationship for RFA of thyroid nodules. Thermal lesions were induced in healthy porcine thyroid glands ex vivo (n = 110) and in vivo (n = 10) using a bipolar radiofrequency system. RF was applied in a power range of 10–20 watts. During the ablation, continuous temperature measurement at a distance of 5 and 10 mm from the applicator was performed. The transversal and axial lesion diameters were measured, and the volume was calculated. Furthermore, enzyme histochemical analysis of the thyroid tissue was performed. The inducible lesion volumes were between 2.43 ± 0.68 cm3 at 10 W and 0.91 ± 0.21 cm3 at 20 W. The maximum temperatures after RF ablation were between 30.0 ± 8.6 °C and 53.5 ± 8.6 °C at a distance of 5 mm and between 44.0 ± 9.7 °C and 61.6 ± 13.9 °C at a distance of 10 mm from the applicator. The histochemical analysis demonstrates a complete loss of NADPH dehydrogenase activity in thermal lesions as a sign of irreversible cell damage. RFA induces reproducible clinically relevant lesions with irreversible cell damage and seems to be suitable for therapy of singular thyroid nodules." @default.
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- W26855876 date "2010-01-01" @default.
- W26855876 modified "2023-10-01" @default.
- W26855876 title "Die bipolare Radiofrequenzablation für noduläre Schilddrüsenerkrankungen – Ex vivo und in vivo Evaluierung einer Dosis-Wirkungs-Beziehung" @default.
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- W26855876 doi "https://doi.org/10.1007/978-3-642-12192-0_45" @default.
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