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- W2685707467 abstract "This study is to explore the effects of two Suppressors of Cytokine Signalling (SOCS) members, namelySOCS-1 and -3, on the regulation of cardiomyocyte hypertrophic response induced by Angiotensin-2(AngII). Rat neonatal cardiomyocytes culture were cultured and treated with Angiotensin II. AfterSOCS1 and SOCS3 inhibition by si-RNA transfection, the cellular hypertrophic response indicated bycell size and protein contain per cell were determined. AngII stimulation dramatically increased thecellular size, protein content and the SOCS-1 and -3 mRNA expression levels in a dose dependentmanner. The SOCS3 protein levels were augmented by AngII treatment while the SOCS1 remainunchanged. SOCS3 si-RNA induced a 75% reduction in SOCS3 protein expression without changingSOCS1 protein. With SOCS3 si-RNA transfection, cells showed a dramatically reduction in cell surfaceand protein content, while the inhibition of SOCS1 did not change the cellular hypertrophy after AngIItreatment. These data suggest that SOCS3 involved in Ang II induced cardiomyocyte hypertrophicresponse." @default.
- W2685707467 created "2017-06-30" @default.
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- W2685707467 date "2017-01-01" @default.
- W2685707467 modified "2023-10-17" @default.
- W2685707467 title "SOCS3 is involved in cardiomyocyte hypertrophy induced by Ang II" @default.
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