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• W2685993713 abstract "Several regulatory systems contribute to bacterial resistance to heavy metals controlling the expression of factors required to eliminate the intoxicant and/or to repair the damage caused by it. In Salmonella, the response to Au ions is mediated by the specific metalloregulator GolS that, among other genes, controls the expression of the RND-efflux pump GesABC. In this work, we demonstrate that CpxR/CpxA, a main cell-envelope stress-responding system, promotes gesABC transcription in the presence of Au ions at neutral pH. Deletion of either cpxA or cpxR, or mutation of the CpxR-binding site identified upstream of the GolS-operator in the gesABC promoter region reduces but does not abrogate the GolS- and Au-dependent activation of gesABC. Au also triggers the activation of the CpxR/CpxA system and deletion of the cpxRA operon severely reduces survival in the presence of the toxic metal. Our results indicate that the coordinated action of GolS and CpxR/CpxA contribute to protecting the cell from severe Au damage." @default.
• W2685993713 created "2017-06-30" @default.
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• W2685993713 date "2017-07-17" @default.
• W2685993713 modified "2023-10-10" @default.
• W2685993713 title "The CpxR/CpxA system contributes to<i>Salmonella</i>gold-resistance by controlling the GolS-dependent<i>gesABC</i>transcription" @default.
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• W2685993713 doi "https://doi.org/10.1111/1462-2920.13837" @default.
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• W2685993713 hasPublicationYear "2017" @default.
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