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- W2687920595 abstract "Transfer RNAs (tRNAs) function in translational machinery and further serves as a source of short non-coding RNAs (ncRNAs). tRNA-derived ncRNAs show differential expression profiles and play roles in many biological processes beyond translation. Molecular mechanisms that shape and regulate their expression profiles are largely unknown. Here, we report the mechanism of biogenesis for tRNA-derived Piwi-interacting RNAs (td-piRNAs) expressed in Bombyx BmN4 cells. In the cells, two cytoplasmic tRNA species, tRNAAspGUC and tRNAHisGUG, served as major sources for td-piRNAs, which were derived from the 5′-part of the respective tRNAs. cP-RNA-seq identified the two tRNAs as major substrates for the 5′-tRNA halves as well, suggesting a previously uncharacterized link between 5′-tRNA halves and td-piRNAs. An increase in levels of the 5′-tRNA halves, induced by BmNSun2 knockdown, enhanced the td-piRNA expression levels without quantitative change in mature tRNAs, indicating that 5′-tRNA halves, not mature tRNAs, are the direct precursors for td-piRNAs. For the generation of tRNAHisGUG-derived piRNAs, BmThg1l-mediated nucleotide addition to −1 position of tRNAHisGUG was required, revealing an important function of BmThg1l in piRNA biogenesis. Our study advances the understanding of biogenesis mechanisms and the genesis of specific expression profiles for tRNA-derived ncRNAs." @default.
- W2687920595 created "2017-06-30" @default.
- W2687920595 creator A5016044802 @default.
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- W2687920595 creator A5054046136 @default.
- W2687920595 creator A5060547780 @default.
- W2687920595 date "2017-06-22" @default.
- W2687920595 modified "2023-09-25" @default.
- W2687920595 title "The biogenesis pathway of tRNA-derived piRNAs in Bombyx germ cells" @default.
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- W2687920595 doi "https://doi.org/10.1093/nar/gkx537" @default.
- W2687920595 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5587776" @default.
- W2687920595 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28645172" @default.
- W2687920595 hasPublicationYear "2017" @default.
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