Matches in SemOpenAlex for { <https://semopenalex.org/work/W2690599584> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2690599584 endingPage "958" @default.
- W2690599584 startingPage "957" @default.
- W2690599584 abstract "Post-transcriptional modification of RNA nucleosides has been implicated as a pivotal regulator of mRNA biology. In this issue of Genes & Development, Ke and colleagues (pp. 990-1006) provide insights into the temporal and spatial distribution of N6-methyladenosine (m6A) in RNA transcripts by analyzing different subcellular fractions. Using a recently developed biochemical approach for detecting m6A, the researchers show that m6A methylations are enriched in exons and are added to transcripts prior to splicing. Although m6A addition is widely thought to be readily reversible, they demonstrate in HeLa cells that once RNA is released from chromatin, the modifications are surprisingly static. This study integrates data from previous publications to clarify conflicting conclusions regarding the role of m6A in mRNA biogenesis and function. Ke and colleagues found that m6A methylation levels negatively correlate with transcript half-life but are not required for most pre-mRNA splicing events." @default.
- W2690599584 created "2017-06-30" @default.
- W2690599584 creator A5035064101 @default.
- W2690599584 creator A5036872396 @default.
- W2690599584 creator A5037428149 @default.
- W2690599584 date "2017-05-15" @default.
- W2690599584 modified "2023-09-28" @default.
- W2690599584 title "Settling the m<sup>6</sup>A debate: methylation of mature mRNA is not dynamic but accelerates turnover" @default.
- W2690599584 cites W1991807334 @default.
- W2690599584 cites W2002458471 @default.
- W2690599584 cites W2011852020 @default.
- W2690599584 cites W2022770379 @default.
- W2690599584 cites W2065847836 @default.
- W2690599584 cites W2071930821 @default.
- W2690599584 cites W2078964320 @default.
- W2690599584 cites W2180404227 @default.
- W2690599584 cites W2632544498 @default.
- W2690599584 doi "https://doi.org/10.1101/gad.302695.117" @default.
- W2690599584 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5495124" @default.
- W2690599584 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28637691" @default.
- W2690599584 hasPublicationYear "2017" @default.
- W2690599584 type Work @default.
- W2690599584 sameAs 2690599584 @default.
- W2690599584 citedByCount "31" @default.
- W2690599584 countsByYear W26905995842017 @default.
- W2690599584 countsByYear W26905995842018 @default.
- W2690599584 countsByYear W26905995842019 @default.
- W2690599584 countsByYear W26905995842020 @default.
- W2690599584 countsByYear W26905995842021 @default.
- W2690599584 countsByYear W26905995842022 @default.
- W2690599584 countsByYear W26905995842023 @default.
- W2690599584 crossrefType "journal-article" @default.
- W2690599584 hasAuthorship W2690599584A5035064101 @default.
- W2690599584 hasAuthorship W2690599584A5036872396 @default.
- W2690599584 hasAuthorship W2690599584A5037428149 @default.
- W2690599584 hasBestOaLocation W26905995841 @default.
- W2690599584 hasConcept C104317684 @default.
- W2690599584 hasConcept C105580179 @default.
- W2690599584 hasConcept C131934819 @default.
- W2690599584 hasConcept C153911025 @default.
- W2690599584 hasConcept C2909856833 @default.
- W2690599584 hasConcept C33288867 @default.
- W2690599584 hasConcept C36823959 @default.
- W2690599584 hasConcept C54355233 @default.
- W2690599584 hasConcept C54458228 @default.
- W2690599584 hasConcept C67705224 @default.
- W2690599584 hasConcept C83640560 @default.
- W2690599584 hasConcept C86803240 @default.
- W2690599584 hasConcept C91965660 @default.
- W2690599584 hasConcept C95444343 @default.
- W2690599584 hasConceptScore W2690599584C104317684 @default.
- W2690599584 hasConceptScore W2690599584C105580179 @default.
- W2690599584 hasConceptScore W2690599584C131934819 @default.
- W2690599584 hasConceptScore W2690599584C153911025 @default.
- W2690599584 hasConceptScore W2690599584C2909856833 @default.
- W2690599584 hasConceptScore W2690599584C33288867 @default.
- W2690599584 hasConceptScore W2690599584C36823959 @default.
- W2690599584 hasConceptScore W2690599584C54355233 @default.
- W2690599584 hasConceptScore W2690599584C54458228 @default.
- W2690599584 hasConceptScore W2690599584C67705224 @default.
- W2690599584 hasConceptScore W2690599584C83640560 @default.
- W2690599584 hasConceptScore W2690599584C86803240 @default.
- W2690599584 hasConceptScore W2690599584C91965660 @default.
- W2690599584 hasConceptScore W2690599584C95444343 @default.
- W2690599584 hasFunder F4320308380 @default.
- W2690599584 hasIssue "10" @default.
- W2690599584 hasLocation W26905995841 @default.
- W2690599584 hasLocation W26905995842 @default.
- W2690599584 hasLocation W26905995843 @default.
- W2690599584 hasLocation W26905995844 @default.
- W2690599584 hasOpenAccess W2690599584 @default.
- W2690599584 hasPrimaryLocation W26905995841 @default.
- W2690599584 hasRelatedWork W2025851750 @default.
- W2690599584 hasRelatedWork W2032224885 @default.
- W2690599584 hasRelatedWork W2039352533 @default.
- W2690599584 hasRelatedWork W2054956547 @default.
- W2690599584 hasRelatedWork W2106625568 @default.
- W2690599584 hasRelatedWork W2168467210 @default.
- W2690599584 hasRelatedWork W2733300197 @default.
- W2690599584 hasRelatedWork W4242521457 @default.
- W2690599584 hasRelatedWork W4294939904 @default.
- W2690599584 hasRelatedWork W4313221961 @default.
- W2690599584 hasVolume "31" @default.
- W2690599584 isParatext "false" @default.
- W2690599584 isRetracted "false" @default.
- W2690599584 magId "2690599584" @default.
- W2690599584 workType "article" @default.