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- W2691674223 abstract "Summary This study examined whether Toll‐like receptors 2 ( TLR 2) contribute to rapid kindling epileptogenesis. A TLR 2 agonist, lipoteichoic acid ( LTA ), LTA antibody ( LTA ‐A), or normal saline (control) was administered daily over 3 consecutive days, unilaterally into ventral hippocampus of adult male Wistar rats. Thirty minutes after the last injection, the animals were subjected to a rapid kindling procedure. The ictogenesis was gauged by comparing afterdischarge threshold ( ADT ) and afterdischarge duration ( ADD ) before the treatments, after the treatments prior to kindling, and 24 h after kindling. Kindling progression and retention were analyzed using video recording. The results showed that before kindling, LTA produced an ADT reduction. Neither LTA nor LTA ‐A affected baseline ADD . On kindling progression, LTA accelerated occurrence of generalized seizures, whereas LTA ‐A delayed this effect. Treatment with LTA ‐A reduced the number of secondary generalized complex partial seizures. Twenty‐four hours after kindling, the rats of both the saline and LTA groups showed increased hippocampal excitability as compared with prekindling parameters. Administration of LTA ‐A prevented kindling‐induced increase of hippocampal excitability. Immunostaining revealed that LTA ‐A attenuated the inflammatory response produced by seizures. These findings suggest that the activation of TLR 2 in the hippocampus may facilitate limbic epileptogenesis." @default.
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- W2691674223 date "2017-06-20" @default.
- W2691674223 modified "2023-10-16" @default.
- W2691674223 title "Regulation of kindling epileptogenesis by hippocampal Toll-like receptors 2" @default.
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- W2691674223 doi "https://doi.org/10.1111/epi.13826" @default.
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