Matches in SemOpenAlex for { <https://semopenalex.org/work/W26921382> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W26921382 abstract "The primary aim of this thesis was to investigate the role of G protein coupled receptors (GPCRs) in insulin secretion and beta-cell survival. The second aim was to determine which pathway is involved in insulin release and beta-cell protection via GPCRs.This has been investigated in three different studies, which concluded thefollowing:Study 1) GPR30 is expressed in female mice pancreatic islets. G-1 (GPR30agonist) and estrogen stimulate insulin secretion and protect cytokine induced apoptosis of beta-cells even in the presence of nuclear receptor (ERalpha and ERbeta ) antagonists.Study 2) The activation of GPR30 mediates insulinotropic effects mainly viacAMP/PKA pathway, anti-apoptotic effects via phosphorylation and activation of CREB, AKT and ERK pathways on female human pancreatic islets. In addition, we have shown here that estrogen and G-1 potentiate the effects of glibenclamide (sulfonylurea) and abolish the inhibitory effects of clonidine on insulin secretion from female human pancreatic islets.Study 3) Protease-activated receptor 2 (PAR-2) belongs to a subfamily of Gprotein-coupled receptors and is expressed in pancreatic islets. Several studies have suggested that the PAR-2 is an important mediator of inflammation. PAR-2 is highly expressed in diabetic vs normal subjects and induction of PAR-2 expression via PAR-2 agonists (SLIKGV or tryptase) mediates apoptosis and reduces the rate of cell proliferation.In this study we have shown that treatment with alpha-1 antitrypsin protectsagainst PAR-2 specific peptide induced apoptosis in human pancreatic islets via a MAP kinase pathway. A1AT displayed PAR-2 antagonistic activities andsuppressed the PAR-2 pro-inflammatory effects. In addition we have shown that the alpha-1 antitrypsin stimulates insulin secretion in a dose-dependent manner. In view of these novel findings we suggest that drugs that can selectively inhibit the activity of PAR-2 and activate GPR30 receptor will be of great benefit in the treatment of diabetes mellitus." @default.
- W26921382 created "2016-06-24" @default.
- W26921382 creator A5066976532 @default.
- W26921382 date "2011-01-01" @default.
- W26921382 modified "2023-09-27" @default.
- W26921382 title "Prevention of beta-cell dysfunction via targeting novel GPCRs in pancreatic islets" @default.
- W26921382 hasPublicationYear "2011" @default.
- W26921382 type Work @default.
- W26921382 sameAs 26921382 @default.
- W26921382 citedByCount "0" @default.
- W26921382 crossrefType "dissertation" @default.
- W26921382 hasAuthorship W26921382A5066976532 @default.
- W26921382 hasConcept C104317684 @default.
- W26921382 hasConcept C121608353 @default.
- W26921382 hasConcept C126322002 @default.
- W26921382 hasConcept C134018914 @default.
- W26921382 hasConcept C135285700 @default.
- W26921382 hasConcept C1629964 @default.
- W26921382 hasConcept C165220095 @default.
- W26921382 hasConcept C166471694 @default.
- W26921382 hasConcept C170493617 @default.
- W26921382 hasConcept C185592680 @default.
- W26921382 hasConcept C2776828364 @default.
- W26921382 hasConcept C2779306644 @default.
- W26921382 hasConcept C2779855799 @default.
- W26921382 hasConcept C530470458 @default.
- W26921382 hasConcept C55493867 @default.
- W26921382 hasConcept C62478195 @default.
- W26921382 hasConcept C71924100 @default.
- W26921382 hasConcept C75217442 @default.
- W26921382 hasConcept C84606932 @default.
- W26921382 hasConcept C86339819 @default.
- W26921382 hasConcept C86803240 @default.
- W26921382 hasConcept C95444343 @default.
- W26921382 hasConcept C96307122 @default.
- W26921382 hasConceptScore W26921382C104317684 @default.
- W26921382 hasConceptScore W26921382C121608353 @default.
- W26921382 hasConceptScore W26921382C126322002 @default.
- W26921382 hasConceptScore W26921382C134018914 @default.
- W26921382 hasConceptScore W26921382C135285700 @default.
- W26921382 hasConceptScore W26921382C1629964 @default.
- W26921382 hasConceptScore W26921382C165220095 @default.
- W26921382 hasConceptScore W26921382C166471694 @default.
- W26921382 hasConceptScore W26921382C170493617 @default.
- W26921382 hasConceptScore W26921382C185592680 @default.
- W26921382 hasConceptScore W26921382C2776828364 @default.
- W26921382 hasConceptScore W26921382C2779306644 @default.
- W26921382 hasConceptScore W26921382C2779855799 @default.
- W26921382 hasConceptScore W26921382C530470458 @default.
- W26921382 hasConceptScore W26921382C55493867 @default.
- W26921382 hasConceptScore W26921382C62478195 @default.
- W26921382 hasConceptScore W26921382C71924100 @default.
- W26921382 hasConceptScore W26921382C75217442 @default.
- W26921382 hasConceptScore W26921382C84606932 @default.
- W26921382 hasConceptScore W26921382C86339819 @default.
- W26921382 hasConceptScore W26921382C86803240 @default.
- W26921382 hasConceptScore W26921382C95444343 @default.
- W26921382 hasConceptScore W26921382C96307122 @default.
- W26921382 hasLocation W269213821 @default.
- W26921382 hasOpenAccess W26921382 @default.
- W26921382 hasPrimaryLocation W269213821 @default.
- W26921382 hasRelatedWork W1943025619 @default.
- W26921382 hasRelatedWork W1963866769 @default.
- W26921382 hasRelatedWork W1983720572 @default.
- W26921382 hasRelatedWork W2019372747 @default.
- W26921382 hasRelatedWork W2019926410 @default.
- W26921382 hasRelatedWork W2062198134 @default.
- W26921382 hasRelatedWork W2071951280 @default.
- W26921382 hasRelatedWork W2079007791 @default.
- W26921382 hasRelatedWork W2082948150 @default.
- W26921382 hasRelatedWork W2102172575 @default.
- W26921382 hasRelatedWork W2129433069 @default.
- W26921382 hasRelatedWork W2565582745 @default.
- W26921382 hasRelatedWork W2598797079 @default.
- W26921382 hasRelatedWork W2741114681 @default.
- W26921382 hasRelatedWork W2787927914 @default.
- W26921382 hasRelatedWork W2953005639 @default.
- W26921382 hasRelatedWork W3038154549 @default.
- W26921382 hasRelatedWork W3164118776 @default.
- W26921382 hasRelatedWork W834052540 @default.
- W26921382 hasRelatedWork W1848592326 @default.
- W26921382 isParatext "false" @default.
- W26921382 isRetracted "false" @default.
- W26921382 magId "26921382" @default.
- W26921382 workType "dissertation" @default.