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- W2694220501 endingPage "82" @default.
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- W2694220501 abstract "The past decade has witnessed a significant expansion of our understanding about the regulated cell death mechanisms beyond apoptosis. The application of chemical biological approaches had played a major role in driving these exciting discoveries. The discovery and use of small molecule probes in cell death research has not only revealed significant insights into the regulatory mechanism of cell death but also provided new drug targets and lead drug candidates for developing therapeutics of human diseases with huge unmet need. Here, we provide an overview of small molecule modulators for necroptosis and ferroptosis, two non-apoptotic cell death mechanisms, and discuss the molecular pathways and relevant pathophysiological mechanisms revealed by the judicial applications of such small molecule probes. We suggest that the development and applications of small molecule probes for non-apoptotic cell death mechanisms provide an outstanding example showcasing the power of chemical biology in exploring novel biological mechanisms." @default.
- W2694220501 created "2017-06-30" @default.
- W2694220501 creator A5060002817 @default.
- W2694220501 creator A5071825445 @default.
- W2694220501 creator A5085141843 @default.
- W2694220501 date "2017-08-01" @default.
- W2694220501 modified "2023-09-27" @default.
- W2694220501 title "Small molecule probes for cellular death machines" @default.
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- W2694220501 doi "https://doi.org/10.1016/j.cbpa.2017.05.007" @default.
- W2694220501 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5581716" @default.
- W2694220501 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28628894" @default.
- W2694220501 hasPublicationYear "2017" @default.
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