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• W2695204427 abstract "The phenomenon of RNA activation (RNAa) was initially discovered by Li and colleagues about a decade ago. Subsequently, gene activation by exogenously expressed small activating RNA has been demonstrated in different cellular contexts by a number of laboratories. Conceivably, endogenously expressed microRNAs may also utilize RNA activation as a cellular mechanism for gene regulation, which may be dysregulated in disease states such as cancer. RNA activation can be applied to gain-of-function studies and holds great promise for disease intervention. This chapter will discuss examples of promoter-targeting microRNAs discovered in recent years and their pathophysiological relevance. I will also briefly touch upon other novel classes of microRNAs with positive gene regulatory roles, including TATA-box-activating microRNAs and enhancer-associated microRNAs." @default.
• W2695204427 created "2017-06-30" @default.
• W2695204427 creator A5079246753 @default.
• W2695204427 date "2017-01-01" @default.
• W2695204427 modified "2023-10-18" @default.
• W2695204427 title "Endogenous miRNAa: miRNA-Mediated Gene Upregulation" @default.
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• W2695204427 doi "https://doi.org/10.1007/978-981-10-4310-9_5" @default.
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