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- W269548989 abstract "In photoreceptor cells cGMP is the second messenger that transduces light into an electrical response. Regulation of cGMP synthesis by Ca2+is one of the key mechanisms by which Caz+exerts negative feedback to the phototransduction cascade in the process of light adaptation.This Ca2+feedback to retinal guanylyl cyclases (Ret-GCs) is conferred by the guanylate cyclase-activating proteins (GCAPs). Mutations in GCAP1 that disrupt the Ca2+regulation of Ret-GCs in vitro have been associated with severe human vision disorders. This chapter focuses on recent data obtained from biochemical and electrophysiological studies of GCAP I /GCAP2 knockout mice and other GCAP transgenic mice, addressing: 1. the quantitative aspects of the Ca2+-feedback to Ret-GCs in regulating the light sensitivity and adaptation in intact rods; 2. functional differences between GCAPI and GCAP2 in intact rod photore-ceptors; and 3. whether GCAP mutants with impaired Ca2+ binding lead to retinal disease in vivo by constitutive activation ofRet-GCs and elevation of intracellular cOMP, as predicted from in vitro studies." @default.
- W269548989 created "2016-06-24" @default.
- W269548989 creator A5002475231 @default.
- W269548989 creator A5026702415 @default.
- W269548989 date "2002-01-01" @default.
- W269548989 modified "2023-10-16" @default.
- W269548989 title "Mouse Models to Study GCAP Functions In Intact Photoreceptors" @default.
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- W269548989 doi "https://doi.org/10.1007/978-1-4615-0121-3_22" @default.
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