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- W2695490918 abstract "Preclinical intrauterine contraception is discussed. These authors favor the possibility that cytolysis of inflammatory cells and endometrial tissue alteration are the most important factors for IUD contraception in humans. As a result of the constant IUD contact with the superficial epithelium of the endometrium a sterile acute inflammatory response develops in which the magnitude of the reaction is dependent on the chemical composition and size of the IUD. A focal ulceration of the superficial epithelium underlying the IUD occurs which may reepithelialize during the luteal phase when there is minimal amount of IUD movement over the surface. An increase has been observed in the number of inflammatory cells present in endometrial tissues in those areas contiguous to the IUD. Biological effects of the IUD uterine milieu include: 1) inhibition of blastocyst development; 2) effect on deoxynucleic acid metabolism; and 3) bactericidal effects. Medicated IUDs have the theoretical advantage of producing complete contraception with few side effects." @default.
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- W2695490918 date "1978-01-01" @default.
- W2695490918 modified "2023-09-23" @default.
- W2695490918 title "Preclinical intrauterine contraception." @default.
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