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- W26989813 abstract "Grb2 induces a variety of biological events including the activation of the Ras-Raf-MEKMAP kinase signal transduction pathway. Compounds able to specifically block the physical interactions involving the SH2 domain of Grb2 could potentially shut-down the above signal transduction pathway and present an intervention point for blocking human malignancies. Structure-based design modifications of the minimal recognition motif of Grb2-SH2 have resulted in highly potent and selective antagonist for this SH2 domain (e.g., phosphopeptide 1, Table 1) [1,2]. We briefly highlight herein our strategy in the identification of a suitable replacement for asparagine in Grb2-SH2 antagonists. Asparagine is the residue that determines specificity for Grb2-SH2 and it has always been present in previously described inhibitors of the above SH2 domain." @default.
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- W26989813 date "2006-05-16" @default.
- W26989813 modified "2023-10-18" @default.
- W26989813 title "Potent Grb2-SH2 antagonists containing asparagine mimetics" @default.
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- W26989813 doi "https://doi.org/10.1007/0-306-46881-6_226" @default.
- W26989813 hasPublicationYear "2006" @default.
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