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- W26996822 abstract "Low frequency noise (LFN) characterized by large pressure amplitude (≥ 90 dB SPL) and low frequency bands (≤ 500 Hz) can lead to structural and ultrastructural modifi cations in the extracellular matrix of several tissues, with an abnormal proliferation of collagen and development of fi brosis. It is not known whether LFN induces similar structural alterations in the ventricular myocardium of rats.Objective The aim of this study was to evaluate and measure the myocardial fi brosis induced by LFN.Methods Two groups of rats were considered: group A with 26 rats continuously exposed to LFN during a period of 3 months; group B with 20 control rats. The hearts were sectioned from the ventricular apex to the atria and the mid-ventricular fragment was selected. Chromotrope-aniline blue (CAB) staining was used for histological observation. The measurement of fi brosis was performed using the computer image analysis Image J software.Results Histological observation with CAB staining showed the presence of collagen deposition between the cardiomyocytes. Fibrosis increased 97.5%, 81.5% and 83.7%, respectively, in the left ventricle, interventricular septum and right ventricle, in exposed rats (P < 0.001). The ratio fi brosis/muscle in left ventricle, interventricular septum and right ventricle was signifi cantly higher in LFN exposed rats (P < 0.001).Conclusions Our study demonstrates a signifi cant myocardial fi brosis induced by low frequency noise in rats. Our results reinforce the need for further experimental and clinical investigations concerning the eff ects of low frequency noise on the heart." @default.
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- W26996822 date "2013-06-01" @default.
- W26996822 modified "2023-10-18" @default.
- W26996822 title "Myocardial fi brosis in rats exposed to low frequency noise" @default.
- W26996822 doi "https://doi.org/10.1080/ac.68.3.2983417" @default.
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