FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2699798832> ?p ?o ?g. }

• W2699798832 endingPage "2482" @default.
• W2699798832 startingPage "2472" @default.
• W2699798832 abstract "Intensive glycemic control (IGC) targeting HbA1c fails to show an unequivocal reduction of macrovascular complications in type 2 diabetes (T2D); however, the underlying mechanisms remain elusive. Epigenetic changes are emerging as important mediators of cardiovascular damage and may play a role in this setting. This study investigated whether epigenetic regulation of the adaptor protein p66Shc, a key driver of mitochondrial oxidative stress, contributes to persistent vascular dysfunction in patients with T2D despite IGC. Thirty-nine patients with uncontrolled T2D (HbA1c &gt;7.5%) and 24 age- and sex-matched healthy control subjects were consecutively enrolled. IGC was implemented for 6 months in patients with T2D to achieve a target HbA1c of ≤7.0%. Brachial artery flow-mediated dilation (FMD), urinary 8-isoprostaglandin F2α (8-isoPGF2α), and epigenetic regulation of p66Shc were assessed at baseline and follow-up. Continuous glucose monitoring was performed to determine the mean amplitude of glycemic excursion (MAGE) and postprandial incremental area under the curve (AUCpp). At baseline, patients with T2D showed impaired FMD, increased urinary 8-isoPGF2α, and p66Shc upregulation in circulating monocytes compared with control subjects. FMD, 8-isoPGF2α, and p66Shc expression were not affected by IGC. DNA hypomethylation and histone 3 acetylation were found on the p66Shc promoter of patients with T2D, and IGC did not change such adverse epigenetic remodeling. Persistent downregulation of methyltransferase DNMT3b and deacetylase SIRT1 may explain the observed p66Shc-related epigenetic changes. MAGE and AUCpp but not HbA1c were independently associated with the altered epigenetic profile on the p66Shc promoter. Hence, glucose fluctuations contribute to chromatin remodeling and may explain persistent vascular dysfunction in patients with T2D with target HbA1c levels." @default.
• W2699798832 created "2017-06-30" @default.
• W2699798832 creator A5007031969 @default.
• W2699798832 creator A5012757068 @default.
• W2699798832 creator A5014079870 @default.
• W2699798832 creator A5027535769 @default.
• W2699798832 creator A5028316168 @default.
• W2699798832 creator A5035872503 @default.
• W2699798832 creator A5045293936 @default.
• W2699798832 creator A5050799541 @default.
• W2699798832 creator A5054282642 @default.
• W2699798832 creator A5061115169 @default.
• W2699798832 creator A5068885715 @default.
• W2699798832 creator A5070855397 @default.
• W2699798832 creator A5073847529 @default.
• W2699798832 date "2017-06-20" @default.
• W2699798832 modified "2023-10-15" @default.
• W2699798832 title "Impact of Glycemic Variability on Chromatin Remodeling, Oxidative Stress, and Endothelial Dysfunction in Patients With Type 2 Diabetes and With Target HbA1c Levels" @default.
• W2699798832 cites W1967265218 @default.
• W2699798832 cites W1981871313 @default.
• W2699798832 cites W1984934982 @default.
• W2699798832 cites W1995993911 @default.
• W2699798832 cites W1997720046 @default.
• W2699798832 cites W2024324080 @default.
• W2699798832 cites W2037449342 @default.
• W2699798832 cites W2042617182 @default.
• W2699798832 cites W2043695663 @default.
• W2699798832 cites W2064424247 @default.
• W2699798832 cites W2071384927 @default.
• W2699798832 cites W2077342495 @default.
• W2699798832 cites W2079118015 @default.
• W2699798832 cites W2083342497 @default.
• W2699798832 cites W2097742361 @default.
• W2699798832 cites W2098036900 @default.
• W2699798832 cites W2103254817 @default.
• W2699798832 cites W2105213045 @default.
• W2699798832 cites W2105731956 @default.
• W2699798832 cites W2108184274 @default.
• W2699798832 cites W2110617730 @default.
• W2699798832 cites W2112821970 @default.
• W2699798832 cites W2120704605 @default.
• W2699798832 cites W2121808478 @default.
• W2699798832 cites W2122648697 @default.
• W2699798832 cites W2123212032 @default.
• W2699798832 cites W2130240144 @default.
• W2699798832 cites W2130695219 @default.
• W2699798832 cites W2139912326 @default.
• W2699798832 cites W2142433177 @default.
• W2699798832 cites W2144125787 @default.
• W2699798832 cites W2144151719 @default.
• W2699798832 cites W2148034645 @default.
• W2699798832 cites W2151202392 @default.
• W2699798832 cites W2158103340 @default.
• W2699798832 cites W2166977140 @default.
• W2699798832 cites W2168261002 @default.
• W2699798832 cites W2187025414 @default.
• W2699798832 cites W2331274940 @default.
• W2699798832 cites W2515836370 @default.
• W2699798832 cites W2619754961 @default.
• W2699798832 cites W3171237122 @default.
• W2699798832 cites W4211172623 @default.
• W2699798832 cites W4242364069 @default.
• W2699798832 doi "https://doi.org/10.2337/db17-0294" @default.
• W2699798832 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28634176" @default.
• W2699798832 hasPublicationYear "2017" @default.
• W2699798832 type Work @default.
• W2699798832 sameAs 2699798832 @default.
• W2699798832 citedByCount "128" @default.
• W2699798832 countsByYear W26997988322017 @default.
• W2699798832 countsByYear W26997988322018 @default.
• W2699798832 countsByYear W26997988322019 @default.
• W2699798832 countsByYear W26997988322020 @default.
• W2699798832 countsByYear W26997988322021 @default.
• W2699798832 countsByYear W26997988322022 @default.
• W2699798832 countsByYear W26997988322023 @default.
• W2699798832 crossrefType "journal-article" @default.
• W2699798832 hasAuthorship W2699798832A5007031969 @default.
• W2699798832 hasAuthorship W2699798832A5012757068 @default.
• W2699798832 hasAuthorship W2699798832A5014079870 @default.
• W2699798832 hasAuthorship W2699798832A5027535769 @default.
• W2699798832 hasAuthorship W2699798832A5028316168 @default.
• W2699798832 hasAuthorship W2699798832A5035872503 @default.
• W2699798832 hasAuthorship W2699798832A5045293936 @default.
• W2699798832 hasAuthorship W2699798832A5050799541 @default.
• W2699798832 hasAuthorship W2699798832A5054282642 @default.
• W2699798832 hasAuthorship W2699798832A5061115169 @default.
• W2699798832 hasAuthorship W2699798832A5068885715 @default.
• W2699798832 hasAuthorship W2699798832A5070855397 @default.
• W2699798832 hasAuthorship W2699798832A5073847529 @default.
• W2699798832 hasBestOaLocation W26997988321 @default.
• W2699798832 hasConcept C104317684 @default.
• W2699798832 hasConcept C126322002 @default.
• W2699798832 hasConcept C127561419 @default.
• W2699798832 hasConcept C134018914 @default.
• W2699798832 hasConcept C150194340 @default.
• W2699798832 hasConcept C190727270 @default.
• W2699798832 hasConcept C2776151105 @default.
• W2699798832 hasConcept C2777142704 @default.

• next