Matches in SemOpenAlex for { <https://semopenalex.org/work/W26998440> ?p ?o ?g. }
- W26998440 abstract "Neutrophils constitute the main immune defense against microbial invasion. When activated, they migrate towards the site of infection where they eliminate any foreign material in an effort to prevent wide-spread tissue damage and ultimately resolve infection. Previous work on neutrophil function in the elderly has highlighted a number of neutrophil effector functions, including phagocytosis, superoxide production and migration that exhibit decreased efficiency suggesting the potential for reduced pathogen clearance in older adults.This thesis reveals a migratory phenotype distinctive of neutrophils isolated from healthy elderly donors (> 60 years) and characterized by a maintained speed of migration (chemokinesis) but with significantly reduced directional migration (chemotaxis) and overall migratory accuracy in response to a range of chemoattractants. This migratory phenotype was shown to be associated with a constitutive basal activation of PI3Kinase in neutrophils isolated from older donors and appears to be a causative factor as treatment of neutrophils with inhibitors selective for PI3Kinase-γ and –δ, was able to restore migratory dynamics. The ‘old-migratory’ phenotype was amenable to correction by pre-incubation with 1nM Simvastatin in vitro and a two-week prescription of 80mg/day Simvastatin in vivo in healthy older adults.The ability of simvastatin to modulate migratory dynamics potentially provides a safe, cost effective intervention to reduce morbidity and mortality from infections in the elderly population." @default.
- W26998440 created "2016-06-24" @default.
- W26998440 creator A5034098151 @default.
- W26998440 date "2014-07-01" @default.
- W26998440 modified "2023-09-23" @default.
- W26998440 title "Neutrophil migration in the healthy elderly : causes and consequences for the resolution of inflammation" @default.
- W26998440 cites W1216511763 @default.
- W26998440 cites W142515415 @default.
- W26998440 cites W146301169 @default.
- W26998440 cites W1479880028 @default.
- W26998440 cites W1481484299 @default.
- W26998440 cites W1482573093 @default.
- W26998440 cites W1483739722 @default.
- W26998440 cites W1489573754 @default.
- W26998440 cites W1490646520 @default.
- W26998440 cites W1496552563 @default.
- W26998440 cites W1503928854 @default.
- W26998440 cites W1508177354 @default.
- W26998440 cites W1513845930 @default.
- W26998440 cites W1514533495 @default.
- W26998440 cites W1518516672 @default.
- W26998440 cites W1524785967 @default.
- W26998440 cites W1527094386 @default.
- W26998440 cites W1530965811 @default.
- W26998440 cites W1539102283 @default.
- W26998440 cites W1540022826 @default.
- W26998440 cites W1544840263 @default.
- W26998440 cites W1551894652 @default.
- W26998440 cites W1559390072 @default.
- W26998440 cites W1568529372 @default.
- W26998440 cites W1575454059 @default.
- W26998440 cites W1577979725 @default.
- W26998440 cites W1578438134 @default.
- W26998440 cites W1585517331 @default.
- W26998440 cites W1586815424 @default.
- W26998440 cites W1598801033 @default.
- W26998440 cites W1606957740 @default.
- W26998440 cites W1658093144 @default.
- W26998440 cites W1672943975 @default.
- W26998440 cites W167981432 @default.
- W26998440 cites W1750158760 @default.
- W26998440 cites W1752964246 @default.
- W26998440 cites W1769382158 @default.
- W26998440 cites W1776803469 @default.
- W26998440 cites W179223508 @default.
- W26998440 cites W1856801024 @default.
- W26998440 cites W1859531625 @default.
- W26998440 cites W1861150097 @default.
- W26998440 cites W186438212 @default.
- W26998440 cites W1865977598 @default.
- W26998440 cites W1887206976 @default.
- W26998440 cites W1907043835 @default.
- W26998440 cites W1908445283 @default.
- W26998440 cites W1910489249 @default.
- W26998440 cites W1920486352 @default.
- W26998440 cites W1921239402 @default.
- W26998440 cites W1938941195 @default.
- W26998440 cites W1940139992 @default.
- W26998440 cites W1952088202 @default.
- W26998440 cites W1965015119 @default.
- W26998440 cites W1965841931 @default.
- W26998440 cites W1966073555 @default.
- W26998440 cites W1966999651 @default.
- W26998440 cites W1967008325 @default.
- W26998440 cites W1967037408 @default.
- W26998440 cites W1967085696 @default.
- W26998440 cites W1968444621 @default.
- W26998440 cites W1969015124 @default.
- W26998440 cites W1969537125 @default.
- W26998440 cites W1969731754 @default.
- W26998440 cites W1969834753 @default.
- W26998440 cites W1971372294 @default.
- W26998440 cites W1972004366 @default.
- W26998440 cites W1972892653 @default.
- W26998440 cites W1973269199 @default.
- W26998440 cites W1973875131 @default.
- W26998440 cites W1975611862 @default.
- W26998440 cites W1976646654 @default.
- W26998440 cites W1976900147 @default.
- W26998440 cites W1977140969 @default.
- W26998440 cites W1977644047 @default.
- W26998440 cites W1977676109 @default.
- W26998440 cites W1977994824 @default.
- W26998440 cites W1978615881 @default.
- W26998440 cites W1979237890 @default.
- W26998440 cites W1979701688 @default.
- W26998440 cites W1980147339 @default.
- W26998440 cites W1980861723 @default.
- W26998440 cites W1981753754 @default.
- W26998440 cites W1981904722 @default.
- W26998440 cites W1982152426 @default.
- W26998440 cites W1982189989 @default.
- W26998440 cites W1983592112 @default.
- W26998440 cites W1983920443 @default.
- W26998440 cites W1984474514 @default.
- W26998440 cites W1984879511 @default.
- W26998440 cites W1985071582 @default.
- W26998440 cites W1985485745 @default.
- W26998440 cites W1986020721 @default.
- W26998440 cites W1986389899 @default.