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- W2700606522 abstract "Summary Recent work has shown that thalamocortical (TC) inputs can be plastic after the developmental critical period has closed, but the mechanism that enables re-establishment of plasticity is unclear. Here, we find that long-term potentiation (LTP) at TC inputs is transiently restored in spared barrel cortex following either a unilateral infra-orbital nerve (ION) lesion, unilateral whisker trimming, or unilateral ablation of the rodent barrel cortex. Restoration of LTP is associated with increased potency at TC input and reactivates anatomical map plasticity induced by whisker follicle ablation. The reactivation of TC LTP is accompanied by reappearance of silent synapses. Both LTP and silent synapse formation are preceded by transient re-expression of synaptic GluN2B-containing N-methyl-D-aspartate (NMDA) receptors, which are required for the reappearance of TC plasticity. These results clearly demonstrate that peripheral sensory deprivation reactivates synaptic plasticity in the mature layer 4 barrel cortex with features similar to the developmental critical period." @default.
- W2700606522 created "2017-06-30" @default.
- W2700606522 creator A5029309237 @default.
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- W2700606522 date "2017-06-01" @default.
- W2700606522 modified "2023-10-14" @default.
- W2700606522 title "Peripheral Sensory Deprivation Restores Critical-Period-like Plasticity to Adult Somatosensory Thalamocortical Inputs" @default.
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- W2700606522 doi "https://doi.org/10.1016/j.celrep.2017.06.018" @default.
- W2700606522 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7443048" @default.
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