FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W27031567> ?p ?o ?g. }

• W27031567 endingPage "3615" @default.
• W27031567 startingPage "3607" @default.
• W27031567 abstract "Abstract Older age is a poor prognosis factor in acute myeloid leukemia (AML). This double-blind trial was designed to test the hypothesis that granulocyte colony-stimulating factor (G-CSF) used as supportive care could improve the treatment of elderly AML patients. Two hundred thirty-four patients 55 or more years of age with a morphologic diagnosis of de novo or secondary AML, French-American-British (FAB) M0-M7, excluding M3, were randomly assigned to a standard induction regimen (daunorubicin at 45 mg/m2 intravenously [IV] on days 1 through 3 and Ara-C at 200 mg/m2 IV continuous infusion on days 1 through 7) plus either placebo or G-CSF (400 μg/m2 IV over 30 minutes once daily). Results are reported here for 211 centrally confirmed cases of non-M3 AML. The two groups were well balanced in demographic, clinical, and hematological parameters, with median ages of 68 years in the G-CSF and 67 years in the placebo groups. The complete response (CR) rate was not significantly better in the G-CSF group: 50% in the placebo and 41% in the G-CSF group (one-tailedP = .89). Median overall survival was also similar, 9 months (95% confidence interval [CI], 7 to 10 months) in the placebo and 6 months (95% CI, 3 to 8 months) in the G-CSF arms (P = .71). We found a significant 15% reduction in the time to neutrophil recovery in the G-CSF group (P = .014). G-CSF had no impact on recovery from thrombocytopenia (P = .80) or duration of first hospitalization (P = .27). When infection complications were evaluated, G-CSF had a beneficial effect on the duration but not on incidence of infection. G-CSF patients had fewer days with fever and shorter duration of antibiotic use. However, there was no difference in the frequency of total documented infections or in the number of fatal infections (19% placebo v 20% G-CSF). In this study of elderly AML patients, G-CSF improved clinical parameters of duration of neutropenia and antibiotic use, but did not change CR rate or survival or shorten hospitalization." @default.
• W27031567 created "2016-06-24" @default.
• W27031567 creator A5005996885 @default.
• W27031567 creator A5013596178 @default.
• W27031567 creator A5049624823 @default.
• W27031567 creator A5054425800 @default.
• W27031567 creator A5056405520 @default.
• W27031567 creator A5061732223 @default.
• W27031567 creator A5076620546 @default.
• W27031567 creator A5080961456 @default.
• W27031567 date "1998-05-15" @default.
• W27031567 modified "2023-10-04" @default.
• W27031567 title "A Double-Blind Placebo-Controlled Trial of Granulocyte Colony-Stimulating Factor in Elderly Patients With Previously Untreated Acute Myeloid Leukemia: A Southwest Oncology Group Study (9031)" @default.
• W27031567 cites W1519562949 @default.
• W27031567 cites W1919339218 @default.
• W27031567 cites W1932121203 @default.
• W27031567 cites W1959575546 @default.
• W27031567 cites W1972125775 @default.
• W27031567 cites W1994956423 @default.
• W27031567 cites W1995634658 @default.
• W27031567 cites W2000275771 @default.
• W27031567 cites W2000366267 @default.
• W27031567 cites W2000578771 @default.
• W27031567 cites W2000838340 @default.
• W27031567 cites W2011564019 @default.
• W27031567 cites W2012866319 @default.
• W27031567 cites W2020851999 @default.
• W27031567 cites W2065910438 @default.
• W27031567 cites W2074972102 @default.
• W27031567 cites W2127463104 @default.
• W27031567 cites W2135729119 @default.
• W27031567 cites W2146737232 @default.
• W27031567 cites W2162731574 @default.
• W27031567 cites W2204518675 @default.
• W27031567 cites W2272025814 @default.
• W27031567 cites W2318674152 @default.
• W27031567 cites W2338649218 @default.
• W27031567 cites W2339692928 @default.
• W27031567 cites W2764775166 @default.
• W27031567 cites W4251253688 @default.
• W27031567 cites W4293241248 @default.
• W27031567 doi "https://doi.org/10.1182/blood.v91.10.3607" @default.
• W27031567 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9572995" @default.
• W27031567 hasPublicationYear "1998" @default.
• W27031567 type Work @default.
• W27031567 sameAs 27031567 @default.
• W27031567 citedByCount "286" @default.
• W27031567 countsByYear W270315672012 @default.
• W27031567 countsByYear W270315672013 @default.
• W27031567 countsByYear W270315672014 @default.
• W27031567 countsByYear W270315672015 @default.
• W27031567 countsByYear W270315672016 @default.
• W27031567 countsByYear W270315672017 @default.
• W27031567 countsByYear W270315672018 @default.
• W27031567 countsByYear W270315672019 @default.
• W27031567 countsByYear W270315672020 @default.
• W27031567 countsByYear W270315672021 @default.
• W27031567 countsByYear W270315672022 @default.
• W27031567 countsByYear W270315672023 @default.
• W27031567 crossrefType "journal-article" @default.
• W27031567 hasAuthorship W27031567A5005996885 @default.
• W27031567 hasAuthorship W27031567A5013596178 @default.
• W27031567 hasAuthorship W27031567A5049624823 @default.
• W27031567 hasAuthorship W27031567A5054425800 @default.
• W27031567 hasAuthorship W27031567A5056405520 @default.
• W27031567 hasAuthorship W27031567A5061732223 @default.
• W27031567 hasAuthorship W27031567A5076620546 @default.
• W27031567 hasAuthorship W27031567A5080961456 @default.
• W27031567 hasBestOaLocation W270315671 @default.
• W27031567 hasConcept C126322002 @default.
• W27031567 hasConcept C141071460 @default.
• W27031567 hasConcept C142724271 @default.
• W27031567 hasConcept C204787440 @default.
• W27031567 hasConcept C27081682 @default.
• W27031567 hasConcept C2776694085 @default.
• W27031567 hasConcept C2777767877 @default.
• W27031567 hasConcept C2778041864 @default.
• W27031567 hasConcept C2778461978 @default.
• W27031567 hasConcept C2778729363 @default.
• W27031567 hasConcept C2781021840 @default.
• W27031567 hasConcept C2781413609 @default.
• W27031567 hasConcept C535046627 @default.
• W27031567 hasConcept C71924100 @default.
• W27031567 hasConcept C90924648 @default.
• W27031567 hasConceptScore W27031567C126322002 @default.
• W27031567 hasConceptScore W27031567C141071460 @default.
• W27031567 hasConceptScore W27031567C142724271 @default.
• W27031567 hasConceptScore W27031567C204787440 @default.
• W27031567 hasConceptScore W27031567C27081682 @default.
• W27031567 hasConceptScore W27031567C2776694085 @default.
• W27031567 hasConceptScore W27031567C2777767877 @default.
• W27031567 hasConceptScore W27031567C2778041864 @default.
• W27031567 hasConceptScore W27031567C2778461978 @default.
• W27031567 hasConceptScore W27031567C2778729363 @default.
• W27031567 hasConceptScore W27031567C2781021840 @default.
• W27031567 hasConceptScore W27031567C2781413609 @default.
• W27031567 hasConceptScore W27031567C535046627 @default.
• W27031567 hasConceptScore W27031567C71924100 @default.

• next