FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W270431131> ?p ?o ?g. }

• W270431131 endingPage "657" @default.
• W270431131 startingPage "652" @default.
• W270431131 abstract "Background Immunoglobulin heavy chain variable region (IgHV) is a well-characterized tumor antigen for B-cell malignancies. It can function as a target for T cell-mediated immune response. Clinical trials of IgHV protein vaccines against lymphoma have demonstrated induction of tumor-specific cytotoxic T lymphocyte (CTL) responses. However, complementary determining regions-based individual vaccines have disadvantages for wide clinical application. Although a recent study demonstrated that immunogenic peptides are derived from framework regions (FR) shared among patients with B-cell lymphoma, how to choose the appropriate peptides for each patient is still unsolved. The aim of this study was to investigate whether immunoglobulin heavy chain FR-derived peptides shared in each IgHV family are potential CTL epitopes presented by B-cell acute lymphoblastic leukemia (B-ALL). Such CTL epitopes might be beneficial to shifting vaccination strategies against B-ALL from individual specificity to family specificity. Methods Seven IgHV gene families were amplified respectively by PCR and sequenced directly from 71 childhood B-ALL cases. Bioinformatics was applied in analyzing characteristics of sequences available and predicting HLA-A*0201-restricted CTL epitopes for each IgHV family. An antigen-specific T cell expansion system was used to generate peptide-specific CTLs. The cytotoxicity of CTLs against B-ALL cells was assessed in the lactate dehydrogenase release assay. Results Complete IgHV rearrangements were identified in all of the 71 B-ALL cases. All of 40 sequences available showed ≥98% homology with the nearest germline IgHV genes, indicating IgHV genes in B-ALL of germline nature. Twelve nonapeptides of high HLA-A*0201-binding scores were obtained from 26 productive IgHV protein sequences. Ten (83%) of the peptides were located in FR1 and FR3 shared among the corresponding IgHV family. CTLs specific for the peptide QLVQSGAEV located in FR1 (3–11) shared among the IgHV1 family could be successfully generated from peripheral blood mononuclear cells of two HLA-A*0201+ healthy donors in vitro and were capable of killing HLA-matched B-ALL cell clones belonging to the IgHV1 family. Conclusion Anti-B-ALL CTLs against immunoglobulin heavy chain FR-derived peptides have family-specific cytotoxicity." @default.
• W270431131 created "2016-06-24" @default.
• W270431131 creator A5060002817 @default.
• W270431131 creator A5073794825 @default.
• W270431131 creator A5084175524 @default.
• W270431131 date "2007-04-01" @default.
• W270431131 modified "2023-09-27" @default.
• W270431131 title "Generation of cytotoxic T lymphocytes specific for B-cell acute lymphoblastic leukemia family-shared peptides derived from immunoglobulin heavy chain framework region" @default.
• W270431131 cites W1500188050 @default.
• W270431131 cites W1544824666 @default.
• W270431131 cites W1656802595 @default.
• W270431131 cites W177504901 @default.
• W270431131 cites W1994048581 @default.
• W270431131 cites W2016671320 @default.
• W270431131 cites W2018592011 @default.
• W270431131 cites W2020814485 @default.
• W270431131 cites W2021171466 @default.
• W270431131 cites W2022198469 @default.
• W270431131 cites W2030050874 @default.
• W270431131 cites W2044982074 @default.
• W270431131 cites W2071909033 @default.
• W270431131 cites W2094094710 @default.
• W270431131 cites W2104401164 @default.
• W270431131 cites W2107921613 @default.
• W270431131 cites W2110947561 @default.
• W270431131 cites W2128015875 @default.
• W270431131 cites W2144004068 @default.
• W270431131 cites W2145736817 @default.
• W270431131 cites W2160686798 @default.
• W270431131 cites W2166831581 @default.
• W270431131 cites W2248092469 @default.
• W270431131 cites W4235004066 @default.
• W270431131 cites W4248628830 @default.
• W270431131 doi "https://doi.org/10.1097/00029330-200704020-00008" @default.
• W270431131 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17517179" @default.
• W270431131 hasPublicationYear "2007" @default.
• W270431131 type Work @default.
• W270431131 sameAs 270431131 @default.
• W270431131 citedByCount "1" @default.
• W270431131 crossrefType "journal-article" @default.
• W270431131 hasAuthorship W270431131A5060002817 @default.
• W270431131 hasAuthorship W270431131A5073794825 @default.
• W270431131 hasAuthorship W270431131A5084175524 @default.
• W270431131 hasBestOaLocation W2704311311 @default.
• W270431131 hasConcept C147483822 @default.
• W270431131 hasConcept C147969180 @default.
• W270431131 hasConcept C154317977 @default.
• W270431131 hasConcept C159654299 @default.
• W270431131 hasConcept C167672396 @default.
• W270431131 hasConcept C195616568 @default.
• W270431131 hasConcept C202751555 @default.
• W270431131 hasConcept C203014093 @default.
• W270431131 hasConcept C2777609679 @default.
• W270431131 hasConcept C2777938653 @default.
• W270431131 hasConcept C2778453870 @default.
• W270431131 hasConcept C2778461978 @default.
• W270431131 hasConcept C54355233 @default.
• W270431131 hasConcept C86803240 @default.
• W270431131 hasConcept C8891405 @default.
• W270431131 hasConcept C96007430 @default.
• W270431131 hasConceptScore W270431131C147483822 @default.
• W270431131 hasConceptScore W270431131C147969180 @default.
• W270431131 hasConceptScore W270431131C154317977 @default.
• W270431131 hasConceptScore W270431131C159654299 @default.
• W270431131 hasConceptScore W270431131C167672396 @default.
• W270431131 hasConceptScore W270431131C195616568 @default.
• W270431131 hasConceptScore W270431131C202751555 @default.
• W270431131 hasConceptScore W270431131C203014093 @default.
• W270431131 hasConceptScore W270431131C2777609679 @default.
• W270431131 hasConceptScore W270431131C2777938653 @default.
• W270431131 hasConceptScore W270431131C2778453870 @default.
• W270431131 hasConceptScore W270431131C2778461978 @default.
• W270431131 hasConceptScore W270431131C54355233 @default.
• W270431131 hasConceptScore W270431131C86803240 @default.
• W270431131 hasConceptScore W270431131C8891405 @default.
• W270431131 hasConceptScore W270431131C96007430 @default.
• W270431131 hasIssue "8" @default.
• W270431131 hasLocation W2704311311 @default.
• W270431131 hasLocation W2704311312 @default.
• W270431131 hasOpenAccess W270431131 @default.
• W270431131 hasPrimaryLocation W2704311311 @default.
• W270431131 hasRelatedWork W2014702019 @default.
• W270431131 hasRelatedWork W2016031396 @default.
• W270431131 hasRelatedWork W2035995139 @default.
• W270431131 hasRelatedWork W2042955728 @default.
• W270431131 hasRelatedWork W2052483994 @default.
• W270431131 hasRelatedWork W2053103268 @default.
• W270431131 hasRelatedWork W2058710260 @default.
• W270431131 hasRelatedWork W2185507573 @default.
• W270431131 hasRelatedWork W2887671764 @default.
• W270431131 hasRelatedWork W3030900991 @default.
• W270431131 hasVolume "120" @default.
• W270431131 isParatext "false" @default.
• W270431131 isRetracted "false" @default.
• W270431131 magId "270431131" @default.
• W270431131 workType "article" @default.