Matches in SemOpenAlex for { <https://semopenalex.org/work/W2704958776> ?p ?o ?g. }
- W2704958776 endingPage "246" @default.
- W2704958776 startingPage "235" @default.
- W2704958776 abstract "Allotransplantation is the most common treatment for end stage kidney, liver, lung, and heart disease. In order to accommodate the allograft, the recipient must be immune-suppressed, to prevent rejection of the graft by the innate and adaptive immune system. Acute rejection has been largely avoided through improved methods of organ procurement, surgical techniques, and immunosuppressive regimens. However, long-term immunosuppression has many drawbacks, leaving patients susceptible to nephrotoxicity, malignancies, and infection. Tolerance is the absolute goal in clinical transplantation, where a patient can be weaned from immunosuppression with no subsequent rejection; however, this is rarely achieved. Withdrawal from these therapies usually results in allograft destruction by the recipient immune system. Here, we outline current knowledge on the immune response to the allograft at the innate and adaptive levels, the impact of withdrawal from immunosuppression and subsequent allograft rejection mediated by a highly activated T cell compartment, and the role of homeostatic proliferation in this setting. Finally, we describe current investigations into novel therapies for the induction of tolerance." @default.
- W2704958776 created "2017-06-30" @default.
- W2704958776 creator A5012065891 @default.
- W2704958776 creator A5030502064 @default.
- W2704958776 date "2017-01-01" @default.
- W2704958776 modified "2023-09-23" @default.
- W2704958776 title "The Immune Response to the Allograft" @default.
- W2704958776 cites W1496266479 @default.
- W2704958776 cites W1524999411 @default.
- W2704958776 cites W1534892633 @default.
- W2704958776 cites W1552791058 @default.
- W2704958776 cites W1571148007 @default.
- W2704958776 cites W1592567691 @default.
- W2704958776 cites W1617193998 @default.
- W2704958776 cites W1741528858 @default.
- W2704958776 cites W1744376040 @default.
- W2704958776 cites W1764700682 @default.
- W2704958776 cites W1785399133 @default.
- W2704958776 cites W1832208952 @default.
- W2704958776 cites W1891182733 @default.
- W2704958776 cites W1892597247 @default.
- W2704958776 cites W1902451611 @default.
- W2704958776 cites W1957599787 @default.
- W2704958776 cites W1967226618 @default.
- W2704958776 cites W1967441582 @default.
- W2704958776 cites W1967710960 @default.
- W2704958776 cites W1968559439 @default.
- W2704958776 cites W1968797624 @default.
- W2704958776 cites W1971278669 @default.
- W2704958776 cites W1973175840 @default.
- W2704958776 cites W1973218385 @default.
- W2704958776 cites W1977121422 @default.
- W2704958776 cites W1977262191 @default.
- W2704958776 cites W1978595696 @default.
- W2704958776 cites W1979444685 @default.
- W2704958776 cites W1981038159 @default.
- W2704958776 cites W1981575054 @default.
- W2704958776 cites W1982023994 @default.
- W2704958776 cites W1983344320 @default.
- W2704958776 cites W1987186481 @default.
- W2704958776 cites W1988227755 @default.
- W2704958776 cites W1991289241 @default.
- W2704958776 cites W1991460349 @default.
- W2704958776 cites W1995250629 @default.
- W2704958776 cites W1997082970 @default.
- W2704958776 cites W1998782859 @default.
- W2704958776 cites W2000765896 @default.
- W2704958776 cites W2001380653 @default.
- W2704958776 cites W2001592750 @default.
- W2704958776 cites W2002325129 @default.
- W2704958776 cites W2002336272 @default.
- W2704958776 cites W2003807422 @default.
- W2704958776 cites W2004829396 @default.
- W2704958776 cites W2006885922 @default.
- W2704958776 cites W2010449491 @default.
- W2704958776 cites W2010708756 @default.
- W2704958776 cites W2011605963 @default.
- W2704958776 cites W2012507629 @default.
- W2704958776 cites W2021046976 @default.
- W2704958776 cites W2022011375 @default.
- W2704958776 cites W2022895499 @default.
- W2704958776 cites W2025635957 @default.
- W2704958776 cites W2027471340 @default.
- W2704958776 cites W2027616201 @default.
- W2704958776 cites W2028702444 @default.
- W2704958776 cites W2028913335 @default.
- W2704958776 cites W2029097180 @default.
- W2704958776 cites W2034004034 @default.
- W2704958776 cites W2034280414 @default.
- W2704958776 cites W2037813506 @default.
- W2704958776 cites W2037916490 @default.
- W2704958776 cites W2037958413 @default.
- W2704958776 cites W2042918108 @default.
- W2704958776 cites W2049776193 @default.
- W2704958776 cites W2051621537 @default.
- W2704958776 cites W2053465471 @default.
- W2704958776 cites W2053717384 @default.
- W2704958776 cites W2053988935 @default.
- W2704958776 cites W2054535836 @default.
- W2704958776 cites W2060640813 @default.
- W2704958776 cites W2063574893 @default.
- W2704958776 cites W2065450496 @default.
- W2704958776 cites W2065828486 @default.
- W2704958776 cites W2066284148 @default.
- W2704958776 cites W2066362593 @default.
- W2704958776 cites W2066626892 @default.
- W2704958776 cites W2068598910 @default.
- W2704958776 cites W2069399162 @default.
- W2704958776 cites W2070068969 @default.
- W2704958776 cites W2070761004 @default.
- W2704958776 cites W2071187698 @default.
- W2704958776 cites W2071205922 @default.
- W2704958776 cites W2071381804 @default.
- W2704958776 cites W2072008518 @default.
- W2704958776 cites W2073024911 @default.
- W2704958776 cites W2077623108 @default.
- W2704958776 cites W2077890795 @default.
- W2704958776 cites W2078305327 @default.