Matches in SemOpenAlex for { <https://semopenalex.org/work/W2706047645> ?p ?o ?g. }
- W2706047645 abstract "Abstract Approaches that integrate molecular network information and tumor genome data could complement gene-based statistical tests to identify likely new cancer genes, but are challenging to validate at scale and their predictive value remains unclear. We developed a robust statistic (NetSig) that integrates protein interaction networks and data from 4,742 tumor exomes and used it to accurately classify known driver genes in 60% of tested tumor types and to predict 62 new candidates. We designed a quantitative experimental framework to compare the in vivo tumorigenic potential of NetSig candidates, known oncogenes and random genes in mice showing that NetSig candidates induce tumors at rates comparable to known oncogenes and 10-fold higher than random genes. By reanalyzing nine tumor-inducing NetSig candidates in 242 patients with oncogene-negative lung adenocarcinomas, we find that two ( AKT2 and TFDP2 ) are significantly amplified. Overall, we illustrate a scalable integrated computational and experimental workflow to expand discovery from cancer genomes." @default.
- W2706047645 created "2017-06-30" @default.
- W2706047645 creator A5001392592 @default.
- W2706047645 creator A5011449332 @default.
- W2706047645 creator A5015642929 @default.
- W2706047645 creator A5016610225 @default.
- W2706047645 creator A5019750129 @default.
- W2706047645 creator A5024943712 @default.
- W2706047645 creator A5029505644 @default.
- W2706047645 creator A5036485783 @default.
- W2706047645 creator A5050276207 @default.
- W2706047645 creator A5054564806 @default.
- W2706047645 creator A5057597328 @default.
- W2706047645 creator A5063875415 @default.
- W2706047645 creator A5069174729 @default.
- W2706047645 creator A5070808897 @default.
- W2706047645 creator A5074629261 @default.
- W2706047645 creator A5090885889 @default.
- W2706047645 date "2017-06-19" @default.
- W2706047645 modified "2023-09-23" @default.
- W2706047645 title "Expanding discovery from cancer genomes by integrating protein network analyses with in vivo tumorigenesis assays" @default.
- W2706047645 cites W2003594259 @default.
- W2706047645 cites W2017283085 @default.
- W2706047645 cites W2042386784 @default.
- W2706047645 cites W2044433401 @default.
- W2706047645 cites W2046831513 @default.
- W2706047645 cites W2081038787 @default.
- W2706047645 cites W2088544963 @default.
- W2706047645 cites W2088891952 @default.
- W2706047645 cites W2095319945 @default.
- W2706047645 cites W2104261859 @default.
- W2706047645 cites W2114031931 @default.
- W2706047645 cites W2121325716 @default.
- W2706047645 cites W2126172213 @default.
- W2706047645 cites W2129973040 @default.
- W2706047645 cites W2130940380 @default.
- W2706047645 cites W2131178190 @default.
- W2706047645 cites W2134034024 @default.
- W2706047645 cites W2141811925 @default.
- W2706047645 cites W2144940507 @default.
- W2706047645 cites W2149372853 @default.
- W2706047645 cites W2157852151 @default.
- W2706047645 cites W2158102062 @default.
- W2706047645 cites W2160981405 @default.
- W2706047645 cites W2168303063 @default.
- W2706047645 cites W2170490448 @default.
- W2706047645 cites W2180481128 @default.
- W2706047645 cites W2274532218 @default.
- W2706047645 cites W2295275561 @default.
- W2706047645 cites W2346025119 @default.
- W2706047645 cites W2346937970 @default.
- W2706047645 cites W953912505 @default.
- W2706047645 doi "https://doi.org/10.1101/151977" @default.
- W2706047645 hasPublicationYear "2017" @default.
- W2706047645 type Work @default.
- W2706047645 sameAs 2706047645 @default.
- W2706047645 citedByCount "1" @default.
- W2706047645 countsByYear W27060476452018 @default.
- W2706047645 crossrefType "posted-content" @default.
- W2706047645 hasAuthorship W2706047645A5001392592 @default.
- W2706047645 hasAuthorship W2706047645A5011449332 @default.
- W2706047645 hasAuthorship W2706047645A5015642929 @default.
- W2706047645 hasAuthorship W2706047645A5016610225 @default.
- W2706047645 hasAuthorship W2706047645A5019750129 @default.
- W2706047645 hasAuthorship W2706047645A5024943712 @default.
- W2706047645 hasAuthorship W2706047645A5029505644 @default.
- W2706047645 hasAuthorship W2706047645A5036485783 @default.
- W2706047645 hasAuthorship W2706047645A5050276207 @default.
- W2706047645 hasAuthorship W2706047645A5054564806 @default.
- W2706047645 hasAuthorship W2706047645A5057597328 @default.
- W2706047645 hasAuthorship W2706047645A5063875415 @default.
- W2706047645 hasAuthorship W2706047645A5069174729 @default.
- W2706047645 hasAuthorship W2706047645A5070808897 @default.
- W2706047645 hasAuthorship W2706047645A5074629261 @default.
- W2706047645 hasAuthorship W2706047645A5090885889 @default.
- W2706047645 hasBestOaLocation W27060476451 @default.
- W2706047645 hasConcept C104317684 @default.
- W2706047645 hasConcept C105795698 @default.
- W2706047645 hasConcept C112313634 @default.
- W2706047645 hasConcept C121608353 @default.
- W2706047645 hasConcept C127716648 @default.
- W2706047645 hasConcept C141231307 @default.
- W2706047645 hasConcept C150194340 @default.
- W2706047645 hasConcept C188082640 @default.
- W2706047645 hasConcept C33923547 @default.
- W2706047645 hasConcept C41008148 @default.
- W2706047645 hasConcept C54355233 @default.
- W2706047645 hasConcept C55105296 @default.
- W2706047645 hasConcept C555283112 @default.
- W2706047645 hasConcept C60644358 @default.
- W2706047645 hasConcept C67339327 @default.
- W2706047645 hasConcept C70721500 @default.
- W2706047645 hasConcept C86803240 @default.
- W2706047645 hasConcept C89128539 @default.
- W2706047645 hasConceptScore W2706047645C104317684 @default.
- W2706047645 hasConceptScore W2706047645C105795698 @default.
- W2706047645 hasConceptScore W2706047645C112313634 @default.
- W2706047645 hasConceptScore W2706047645C121608353 @default.
- W2706047645 hasConceptScore W2706047645C127716648 @default.
- W2706047645 hasConceptScore W2706047645C141231307 @default.