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• W270754804 abstract "formed radiochemically, using 3H-tyramine as substrate. NCR was estimated both fluorometrically and in the spectrophotometer. Both MAO and NCR were found to increase with the age of the animal which in the age groups studied, closely paralleled the increase in the weights of the hearts. Following adrenalectomy there was a further increase in enzyme activity superimposed upon that due to the growth of the animal. This increase reached a maximum 14 days after operation. The MAO remained at this level for at least a further 14 days, but the NCR activity began to fall towards normal within a week. The half-life of the MAO in the hearts of both adrenalectomized and normal animals was measured by irreversibly inhibiting the enzyme with pargyline (25 mg/kg, s.c.) and following the synthesis of new enzyme over a period of several days. Three groups of adrenalectomized rats were used together with matched controls. The first group, with a mean body weight of 155 g, were given pargyline immediately after operation. The half-life of the MAO was 6-2 days compared with 6-7 for the controls. The second group were pargyline treated 13 days after adrenalectomy. The MAO half-life was now 10-1 in the operated animals compared with 10-2 for the controls, for a mean body weight of 230 g. In the third group, with a mean body weight of 340 g, the MAO half-lives were 15 4 and 17-6 days in adrenalectomized and control animals respectively. At no time was there a significant difference in the half-life of the enzyme between operated and control rats. Calculations of the half-lives of both MAO and NCR from the changes in enzyme activity following adrenalectomy gave values of 6-3 and 6-5 days respectively for the two enzymes in animals weighing 155 g. The breakdown of NCR calculated from its return to the normal level gave a half-time of 11.5 for rats weighing 260 g. All values obtained for the half-lives of both enzymes showed a close linear relationship to either the body weight or to the heart weight of the animals. As the rats grow older, the rate of destruction of both MAO and NCR decreases, which may account for the observed increase in enzymic activity seen with age. Adrenalectomy has no apparent effect upon this ageing process." @default.
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• W270754804 date "1972-11-01" @default.
• W270754804 modified "2023-09-23" @default.
• W270754804 title "Catecholamine induced contractures in denervated muscle." @default.
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