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- W2707896172 abstract "Liver fibrosis and subsequent cirrhosis continues to be a major health problem. Recent understanding of the pathophysiology of the process will, hopefully, give an insight into the possible treatment of the condition. We have reviewed the research in the area of liver fibrosis and the roles of transforming growth factor β (TGFβ) from the literature. The relationship between liver fibrosis and tamoxifen was also reviewed. The pathophysiology of liver fibrogenesis is reviewed. TGFβ is the key-player in the initiation and perpetuation of liver fibrogenesis. Tamoxifen, on the other hand, enhances the TGFβ-mediated process of fibrogenesis. Possible therapeutic interventions, based on the pathophysiological pathways of liver fibrosis, are discussed." @default.
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- W2707896172 date "1999-01-01" @default.
- W2707896172 modified "2023-09-26" @default.
- W2707896172 title "Liver fibrogenesis: effects of transforming growth factor β and tamoxifen, and possible treatment modalities" @default.
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- W2707896172 doi "https://doi.org/10.1016/s1365-182x(17)30642-1" @default.
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