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• W27105653 abstract "In the last five years we have been studying the phenotypic changes that the rabbit bladder wall undergoes at the level of serosal compartment in experimental models known to induce an increase of organ mass. Gene expression of submesothelial mesenchymal cells (SMMC) were monitored by a panel of monoclonal antibodies specific for smooth muscle (SM) and non-muscle (NM) differentiation markers. Both the phenotypic profile and growth pattern of these cells were compared in developing, obstructed and regenerating bladder. In the obstruction model, the whole organ hypertrophy is accompanied by a hypertrophy/hyperploidy of SM cells and a marked serosal thickening due to the proliferation of SMMC. Concomitant with changes in the growth pattern of detrusor muscle, there is a SM cell phenotype switching to that of fetal type. The hyperplastic response of serosal compartment was paralleled by a spatiotemporal modification of the differentiation status of these cells, that was related to the shift of the submesothelial elastic membrane towards the underlying detrusor muscle. As a result, the thickened serosa was divided into two tissues: the ‘extrinsic’ and the ‘intrinsic’ region with respect to this membrane. The inherent differentiation plasticity of SMMC was evidenced by the two-step cellular innervation-independent conversion process from resident fibroblast to myofibroblast (or keratin-containing myofibroblast) to fetal-type SM cell which took place in the obstructed bladder. In the regenerating bladder wall this process was faster and small bundles of SM cells could be observed at both sides of the elastic membrane in the thickened serosa. Similarly, fibroblast-like interstitial cells participated in the detrusor muscle regeneration by a recruitment and subsequent differentiation within the regenerating SM cell fasicles. In chemically denervated bladder, however, interstitial cells could complete their SM-type differentiation before being incorporated in newly formed SM cell bundles, suggesting a repressive role of innervation on differentiation of these cells. Infusion experiments delivering both growth factors and cytokine to the bladder surface indicated that TGFβ1 was able to reproduce serosal thickening, transition from SMMC to myofibroblast and formation of small bundles of SM cells near the elastic membrane." @default.
• W27105653 created "2016-06-24" @default.
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• W27105653 date "1999-01-01" @default.
• W27105653 modified "2023-09-27" @default.
• W27105653 title "Serosal Thickening, Smooth Muscle Cell Growth, and Phenotypic Changes in the Rabbit Bladder Wall During Outflow Obstruction and Regeneration" @default.
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• W27105653 doi "https://doi.org/10.1007/978-1-4615-4737-2_6" @default.
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• W27105653 hasPublicationYear "1999" @default.
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