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• W2710596543 endingPage "101" @default.
• W2710596543 startingPage "88" @default.
• W2710596543 abstract "More Americans are consuming diets higher in saturated fats and refined sugars than ever before, and based on increasing obesity rates, this is a growing trend among older adults as well. While high saturated fat diet (HFD) consumption has been shown to sensitize the inflammatory response to a subsequent immune challenge in young adult rats, the inflammatory effect of HFD in the already-vulnerable aging brain has not yet been assessed. Here, we explored whether short-term (3 days) consumption of HFD would serve as a neuroinflammatory trigger in aging animals, leading to cognitive deficits. HFD impaired long-term contextual (hippocampal dependent) and auditory-cued fear (amygdalar dependent) memory in aged, but not young adult rats. Short-term memory performance for both tasks was intact, suggesting that HFD impairs memory consolidation processes. Microglial markers of activation Iba1 and cd11b were only increased in the aged rats, while MHCII was further amplified by HFD. Furthermore, these HFD-induced long-term memory impairments were accompanied by IL-1β protein increases in both the hippocampus and amygdala in aged rats. Central administration of IL-1RA in aged rats following conditioning mitigated both contextual and auditory-cued fear memory impairments caused by HFD, strongly suggesting that IL-1β plays a critical role in these effects. Voluntary wheel running, known to have anti-inflammatory effects in the hippocampus, rescued hippocampal-dependent but not amygdalar-dependent memory impairments caused by HFD. Together, these data suggest that short-term consumption of HFD can lead to memory deficits and significant brain inflammation in the aged animal, and strongly suggest that appropriate diet is crucial for cognitive health." @default.
• W2710596543 created "2017-06-30" @default.
• W2710596543 creator A5006669413 @default.
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• W2710596543 creator A5058063005 @default.
• W2710596543 date "2017-10-01" @default.
• W2710596543 modified "2023-10-14" @default.
• W2710596543 title "High-fat diet and aging interact to produce neuroinflammation and impair hippocampal- and amygdalar-dependent memory" @default.
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• W2710596543 doi "https://doi.org/10.1016/j.neurobiolaging.2017.06.014" @default.
• W2710596543 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5581696" @default.
• W2710596543 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28719855" @default.
• W2710596543 hasPublicationYear "2017" @default.
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