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- W2711700716 abstract "Cytosolic phospholipase A2α (cPLA2α) is a key enzyme in regulation of inflammation process and neuromembrane homeostasis, both of which are critical in pathogenesis of Alzheimer’s diseases. By hybride APP/PS1 Tg-AD mice with cPLA2α knockout mice, three lines of APP/PS1 Tg-AD mice were produced with genotypes of cPLA2α+/+, cPLA2α+/− and cPLA2α−/−. Compared to cPLA2α+/+ Tg-AD mice, the amyloid plaque formation was significantly downregulated in the brain of cPLA2α+/− Tg-AD mice, but not in cPLA2α−/− Tg-AD mice. The reactive gliosis were also significantly downregulated in both cPLA2α+/− and cPLA2α−/− Tg-AD mouse lines. The paradoxical effects of cPLA2α on the amyloid plaques reveal a complex role of cPLA2α in pathogenesis of AD and could be a potential target for prevention and treatment of AD." @default.
- W2711700716 created "2017-06-30" @default.
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- W2711700716 date "2017-09-01" @default.
- W2711700716 modified "2023-10-16" @default.
- W2711700716 title "Heterozygous knockout of cytosolic phospholipase A 2α attenuates Alzheimer’s disease pathology in APP/PS1 transgenic mice" @default.
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- W2711700716 doi "https://doi.org/10.1016/j.brainres.2017.06.021" @default.
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