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- W2712031882 abstract "This study presents experimental data of a fluidized-bed bioreactor for the cultivation of encapsulated pancreatic beta-cells. The fluidization quality for the bioreactor was evaluated at different flow rate using bed-expansion parameters. Homogeneous distribution of microcapsules was achieved at a flow rate of 2000 μL/min. This enabled efficient contact between the encapsulated cells and medium, which contributed to high cell viability. Microcapsule breakage was <4% on day 7 and confirmed the stability of encapsulated systems under fluidized culture. Importantly, endocrine beta-cells cultured in the bioreactor were shown to be dramatically more responsive to changes in glucose concentration compared to static culture (P < 0.001). On the basis of these results, cultivation of encapsulated cells in a fluidized bioreactor, especially for pancreatic beta-cells that are limited in supply, is a promising approach to address the lack of a safe method for storage and handling of cells between laboratories and cl..." @default.
- W2712031882 created "2017-06-30" @default.
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- W2712031882 date "2017-07-03" @default.
- W2712031882 modified "2023-10-03" @default.
- W2712031882 title "Encapsulation and Fluidization Maintains the Viability and Glucose Sensitivity of Beta-Cells" @default.
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- W2712031882 doi "https://doi.org/10.1021/acsbiomaterials.7b00191" @default.
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