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- W271574229 abstract "Cultured Chinese hamster cells were irradiated with californium-252 neutrons and gamma rays at dose rates of 148 cGy/h and 68 cGy/h, respectively. Survival curves were obtained with and without 60 ..mu..g/ml of boron-10 in the culture medium. When the data were fitted to the linear-quadratic model of cell survival it was found that boron increased ..cap alpha.. (the 'single-hit' parameter) by 32% and decreased ..beta.. (the ''double-hit'' parameter) by 8%. The ..cap alpha../..beta.. ratio increased to 4.34 Gy in the presence of boron from 3.03 Gy in its absence. This translated to an 8% reduction in californium dose needed to effect 10% cell survival. It is concluded that there may be a sufficiently high thermal neutron fluence present during californium brachytherapy for boron-neutron capture dose augmentation to be feasible. Treatment of inoperable solid local tumors would be of possible benefit." @default.
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- W271574229 date "1986-01-01" @default.
- W271574229 modified "2023-09-26" @default.
- W271574229 title "Potential for boron neutron capture enhancement of Cf-252 brachytherapy treatment of localized tumors" @default.
- W271574229 hasPublicationYear "1986" @default.
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