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• W2715922000 endingPage "1876" @default.
• W2715922000 startingPage "1861" @default.
• W2715922000 abstract "CD4 T cells, including T regulatory cells (Treg cells) and effector T helper cells (Th cells), and recently identified innate lymphoid cells (ILCs) play important roles in host defense and inflammation. Both CD4 T cells and ILCs can be classified into distinct lineages based on their functions and the expression of lineage-specific genes, including those encoding effector cytokines, cell surface markers, and key transcription factors. It was first recognized that each lineage expresses a specific master transcription factor and the expression of these factors is mutually exclusive because of cross-regulation among these factors. However, recent studies indicate that the master regulators are often coexpressed. Furthermore, the expression of master regulators can be dynamic and quantitative. In this review, we will first discuss similarities and differences between the development and functions of CD4 T cell and ILC subsets and then summarize recent literature on quantitative, dynamic, and cell type-specific balance between the master transcription factors in determining heterogeneity and plasticity of these subsets." @default.
• W2715922000 created "2017-06-30" @default.
• W2715922000 creator A5019970599 @default.
• W2715922000 creator A5082435601 @default.
• W2715922000 date "2017-06-19" @default.
• W2715922000 modified "2023-10-01" @default.
• W2715922000 title "Dynamic balance between master transcription factors determines the fates and functions of CD4 T cell and innate lymphoid cell subsets" @default.
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