FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2715957170> ?p ?o ?g. }

• W2715957170 abstract "Hyperosmolar therapy with either mannitol or hypertonic saline (HTS) is commonly used in the treatment of intracranial hypertension (ICH). In vitro data indicate that both mannitol and HTS affect coagulation and platelet function in dogs. The aim of this study was to compare the effects of 20% mannitol and 7.2% HTS on whole blood coagulation using rotational thromboelastometry (ROTEM®) and platelet function using a platelet function analyzer (PFA®) in dogs with suspected ICH. Thirty client-owned dogs with suspected ICH needing osmotherapy were randomized to receive either 20% mannitol (5 ml/kg IV over 15 min) or 7.2% HTS (4 ml/kg IV over 5 min). ROTEM® (EXTEM® and FIBTEM® assays) and PFA® analyses (collagen/ADP cartridges) were performed before (T0), as well as 5 (T5), 60 (T60) and 120 (T120) minutes after administration of HTS or mannitol. Data at T5, T60 and T120 were analyzed as a percentage of values at T0 for comparison between groups, and as absolute values for comparison between time points, respectively.No significant difference was found between the groups for the percentage change of any parameter at any time point except for FIBTEM® clotting time. Within each group, no significant difference was found between time points for any parameter except for FIBTEM® clotting time in the HTS group, and EXTEM® and FIBTEM® maximum clot firmness in the mannitol group. Median ROTEM® values lay within institutional reference intervals in both groups at all time points, whereas median PFA® values were above the reference intervals at T5 (both groups) and T60 (HTS group).Using currently recommended doses, mannitol and HTS do not differ in their effects on whole blood coagulation and platelet function in dogs with suspected ICH. Moreover, no relevant impairment of whole blood coagulation was found following treatment with either solution, whereas a short-lived impairment of platelet function was found after both solutions." @default.
• W2715957170 created "2017-06-30" @default.
• W2715957170 creator A5014786978 @default.
• W2715957170 creator A5059850163 @default.
• W2715957170 creator A5071841735 @default.
• W2715957170 creator A5074596227 @default.
• W2715957170 creator A5018162119 @default.
• W2715957170 date "2017-06-19" @default.
• W2715957170 modified "2023-10-18" @default.
• W2715957170 title "Comparison of the effects of 7.2% hypertonic saline and 20% mannitol on whole blood coagulation and platelet function in dogs with suspected intracranial hypertension - a pilot study" @default.
• W2715957170 cites W1504043086 @default.
• W2715957170 cites W1540755901 @default.
• W2715957170 cites W1567336511 @default.
• W2715957170 cites W1573922084 @default.
• W2715957170 cites W1943875243 @default.
• W2715957170 cites W1967721008 @default.
• W2715957170 cites W1977834966 @default.
• W2715957170 cites W1977979849 @default.
• W2715957170 cites W1985000769 @default.
• W2715957170 cites W1991144596 @default.
• W2715957170 cites W1994795952 @default.
• W2715957170 cites W1995539809 @default.
• W2715957170 cites W1999666547 @default.
• W2715957170 cites W2010068826 @default.
• W2715957170 cites W2028215458 @default.
• W2715957170 cites W2082304950 @default.
• W2715957170 cites W2082478733 @default.
• W2715957170 cites W2088977315 @default.
• W2715957170 cites W2102018474 @default.
• W2715957170 cites W2107254922 @default.
• W2715957170 cites W2131587771 @default.
• W2715957170 cites W2134612927 @default.
• W2715957170 cites W2138096586 @default.
• W2715957170 cites W2139044523 @default.
• W2715957170 cites W2144244588 @default.
• W2715957170 cites W2157353581 @default.
• W2715957170 cites W2159571378 @default.
• W2715957170 cites W2162801778 @default.
• W2715957170 cites W2165928642 @default.
• W2715957170 cites W2170144645 @default.
• W2715957170 cites W2172553649 @default.
• W2715957170 cites W2176314897 @default.
• W2715957170 cites W2522738478 @default.
• W2715957170 cites W2559748654 @default.
• W2715957170 cites W2560774023 @default.
• W2715957170 cites W2606993095 @default.
• W2715957170 cites W4229594069 @default.
• W2715957170 doi "https://doi.org/10.1186/s12917-017-1108-2" @default.
• W2715957170 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5477108" @default.
• W2715957170 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28629456" @default.
• W2715957170 hasPublicationYear "2017" @default.
• W2715957170 type Work @default.
• W2715957170 sameAs 2715957170 @default.
• W2715957170 citedByCount "15" @default.
• W2715957170 countsByYear W27159571702019 @default.
• W2715957170 countsByYear W27159571702020 @default.
• W2715957170 countsByYear W27159571702021 @default.
• W2715957170 countsByYear W27159571702022 @default.
• W2715957170 crossrefType "journal-article" @default.
• W2715957170 hasAuthorship W2715957170A5014786978 @default.
• W2715957170 hasAuthorship W2715957170A5018162119 @default.
• W2715957170 hasAuthorship W2715957170A5059850163 @default.
• W2715957170 hasAuthorship W2715957170A5071841735 @default.
• W2715957170 hasAuthorship W2715957170A5074596227 @default.
• W2715957170 hasBestOaLocation W27159571701 @default.
• W2715957170 hasConcept C117277713 @default.
• W2715957170 hasConcept C126322002 @default.
• W2715957170 hasConcept C1621761 @default.
• W2715957170 hasConcept C185592680 @default.
• W2715957170 hasConcept C26809991 @default.
• W2715957170 hasConcept C2777397205 @default.
• W2715957170 hasConcept C2777664302 @default.
• W2715957170 hasConcept C2777987278 @default.
• W2715957170 hasConcept C2778382381 @default.
• W2715957170 hasConcept C2778445172 @default.
• W2715957170 hasConcept C2778881276 @default.
• W2715957170 hasConcept C3017567848 @default.
• W2715957170 hasConcept C42219234 @default.
• W2715957170 hasConcept C55493867 @default.
• W2715957170 hasConcept C71924100 @default.
• W2715957170 hasConcept C77171857 @default.
• W2715957170 hasConcept C89560881 @default.
• W2715957170 hasConceptScore W2715957170C117277713 @default.
• W2715957170 hasConceptScore W2715957170C126322002 @default.
• W2715957170 hasConceptScore W2715957170C1621761 @default.
• W2715957170 hasConceptScore W2715957170C185592680 @default.
• W2715957170 hasConceptScore W2715957170C26809991 @default.
• W2715957170 hasConceptScore W2715957170C2777397205 @default.
• W2715957170 hasConceptScore W2715957170C2777664302 @default.
• W2715957170 hasConceptScore W2715957170C2777987278 @default.
• W2715957170 hasConceptScore W2715957170C2778382381 @default.
• W2715957170 hasConceptScore W2715957170C2778445172 @default.
• W2715957170 hasConceptScore W2715957170C2778881276 @default.
• W2715957170 hasConceptScore W2715957170C3017567848 @default.
• W2715957170 hasConceptScore W2715957170C42219234 @default.
• W2715957170 hasConceptScore W2715957170C55493867 @default.
• W2715957170 hasConceptScore W2715957170C71924100 @default.
• W2715957170 hasConceptScore W2715957170C77171857 @default.
• W2715957170 hasConceptScore W2715957170C89560881 @default.
• W2715957170 hasIssue "1" @default.

• next