FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2717381632> ?p ?o ?g. }

• W2717381632 endingPage "67" @default.
• W2717381632 startingPage "58" @default.
• W2717381632 abstract "The strategy of vascular tissue engineering is to create a vascular substitute by combining autologous vascular cells with a tubular-shaped biodegradable scaffold. We have previously developed a novel electrospun bilayered vascular scaffold that provides proper biological and biomechanical properties as well as structural configuration. In this study, we investigated the clinical feasibility of a cellularized vascular scaffold in a preclinical large animal model. We fabricated the cellularized vascular construct with autologous endothelial progenitor cell (EPC)-derived endothelial cells (ECs) and smooth muscle cells (SMCs) followed by a pulsatile bioreactor preconditioning. This fully cellularized vascular construct was tested in a sheep carotid arterial interposition model. After preconditioning, confluent and mature EC and SMC layers in the scaffold were achieved. The cellularized constructs sustained the structural integrity with a high degree of graft patency without eliciting an inflammatory response over the course of the 6-month period in sheep. Moreover, the matured EC coverage on the lumen and a thick smooth muscle layer were formed at 6months after transplantation. We demonstrated that electrospun bilayered vascular scaffolds in conjunction with autologous vascular cells may be a clinically applicable alternative to traditional prosthetic vascular graft substitutes.This study demonstrates the utility of tissue engineering to provide platform technologies for rehabilitation of patients recovering from severe, devastating cardiovascular diseases. The long-term goal is to provide alternatives to vascular grafting using bioengineered blood vessels derived from an autologous cell source with a functionalized vascular scaffold. This novel bilayered vascular construct for engineering blood vessels is designed to offer off-the-shelf availability for clinical translation." @default.
• W2717381632 created "2017-06-30" @default.
• W2717381632 creator A5007726050 @default.
• W2717381632 creator A5030802910 @default.
• W2717381632 creator A5033818664 @default.
• W2717381632 creator A5044444976 @default.
• W2717381632 creator A5066549957 @default.
• W2717381632 creator A5068608191 @default.
• W2717381632 creator A5091531148 @default.
• W2717381632 creator A5055779558 @default.
• W2717381632 date "2017-09-01" @default.
• W2717381632 modified "2023-10-02" @default.
• W2717381632 title "Electrospun vascular scaffold for cellularized small diameter blood vessels: A preclinical large animal study" @default.
• W2717381632 cites W1590987349 @default.
• W2717381632 cites W1968336848 @default.
• W2717381632 cites W1970403687 @default.
• W2717381632 cites W1973230733 @default.
• W2717381632 cites W1975349241 @default.
• W2717381632 cites W1981976329 @default.
• W2717381632 cites W1989704675 @default.
• W2717381632 cites W1991016293 @default.
• W2717381632 cites W1991793133 @default.
• W2717381632 cites W1994589849 @default.
• W2717381632 cites W2001822903 @default.
• W2717381632 cites W2003797941 @default.
• W2717381632 cites W2004181539 @default.
• W2717381632 cites W2010748138 @default.
• W2717381632 cites W2011491819 @default.
• W2717381632 cites W2023166500 @default.
• W2717381632 cites W2032208424 @default.
• W2717381632 cites W2036629390 @default.
• W2717381632 cites W2040165312 @default.
• W2717381632 cites W2049909810 @default.
• W2717381632 cites W2054931962 @default.
• W2717381632 cites W2063268821 @default.
• W2717381632 cites W2063736240 @default.
• W2717381632 cites W2074470876 @default.
• W2717381632 cites W2093540514 @default.
• W2717381632 cites W2103720021 @default.
• W2717381632 cites W2118816370 @default.
• W2717381632 cites W2119249751 @default.
• W2717381632 cites W2124600270 @default.
• W2717381632 cites W2126254515 @default.
• W2717381632 cites W2144824258 @default.
• W2717381632 cites W2146038929 @default.
• W2717381632 cites W2149612904 @default.
• W2717381632 cites W2152296190 @default.
• W2717381632 cites W2164883990 @default.
• W2717381632 cites W2168654826 @default.
• W2717381632 cites W2321658691 @default.
• W2717381632 cites W3020860431 @default.
• W2717381632 cites W4234827303 @default.
• W2717381632 doi "https://doi.org/10.1016/j.actbio.2017.06.027" @default.
• W2717381632 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28642016" @default.
• W2717381632 hasPublicationYear "2017" @default.
• W2717381632 type Work @default.
• W2717381632 sameAs 2717381632 @default.
• W2717381632 citedByCount "85" @default.
• W2717381632 countsByYear W27173816322017 @default.
• W2717381632 countsByYear W27173816322018 @default.
• W2717381632 countsByYear W27173816322019 @default.
• W2717381632 countsByYear W27173816322020 @default.
• W2717381632 countsByYear W27173816322021 @default.
• W2717381632 countsByYear W27173816322022 @default.
• W2717381632 countsByYear W27173816322023 @default.
• W2717381632 crossrefType "journal-article" @default.
• W2717381632 hasAuthorship W2717381632A5007726050 @default.
• W2717381632 hasAuthorship W2717381632A5030802910 @default.
• W2717381632 hasAuthorship W2717381632A5033818664 @default.
• W2717381632 hasAuthorship W2717381632A5044444976 @default.
• W2717381632 hasAuthorship W2717381632A5055779558 @default.
• W2717381632 hasAuthorship W2717381632A5066549957 @default.
• W2717381632 hasAuthorship W2717381632A5068608191 @default.
• W2717381632 hasAuthorship W2717381632A5091531148 @default.
• W2717381632 hasBestOaLocation W27173816321 @default.
• W2717381632 hasConcept C126322002 @default.
• W2717381632 hasConcept C131631996 @default.
• W2717381632 hasConcept C136229726 @default.
• W2717381632 hasConcept C141071460 @default.
• W2717381632 hasConcept C166397571 @default.
• W2717381632 hasConcept C192562407 @default.
• W2717381632 hasConcept C201750760 @default.
• W2717381632 hasConcept C2777663904 @default.
• W2717381632 hasConcept C2779395532 @default.
• W2717381632 hasConcept C28328180 @default.
• W2717381632 hasConcept C2911091166 @default.
• W2717381632 hasConcept C2992686903 @default.
• W2717381632 hasConcept C3017963558 @default.
• W2717381632 hasConcept C49892992 @default.
• W2717381632 hasConcept C59822182 @default.
• W2717381632 hasConcept C71924100 @default.
• W2717381632 hasConcept C79191276 @default.
• W2717381632 hasConcept C86803240 @default.
• W2717381632 hasConcept C89429830 @default.
• W2717381632 hasConcept C95444343 @default.
• W2717381632 hasConceptScore W2717381632C126322002 @default.
• W2717381632 hasConceptScore W2717381632C131631996 @default.
• W2717381632 hasConceptScore W2717381632C136229726 @default.

• next