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- W2717738771 abstract "Sickle cell disease is the most frequent genetic disease in France, concerning 400 newborns each year. The management of these Afro-Caribbean patients requires frequent transfusions from Caucasian donors. Due to important erythroid antigenic differences between Caucasian and African, the prevalence of allo-immunization is high in this population with a risk of transfusional impasse. Allogeneic stem cell transplantation is the only curative treatment for this disease and the replacement of red cells and lymphocytes of the sickle cell patient by those of the donor can also resolve the transfusional impasse. However, a close consultation between physicians from the blood bank and transplantation unit will be required for the choice of conditioning regimen and GvH prophylaxis in order to ensure the transition from a mixed chimerism to the full donor curative graft." @default.
- W2717738771 created "2017-06-30" @default.
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- W2717738771 date "2017-09-01" @default.
- W2717738771 modified "2023-10-03" @default.
- W2717738771 title "Dans la drépanocytose, la greffe est-elle une alternative à l’impasse transfusionnelle ?" @default.
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- W2717738771 doi "https://doi.org/10.1016/j.tracli.2017.06.007" @default.
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