FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2717967574> ?p ?o ?g. }

• W2717967574 endingPage "985" @default.
• W2717967574 startingPage "977" @default.
• W2717967574 abstract "To evaluate the population pharmacokinetics and pharmacodynamic target attainment of vancomycin in neonates with a contemporary ¼-inch extracorporeal life support circuit with a Quadrox-iD Pediatric oxygenator (Maquet Cardiovascular, LLC, Wayne, NJ).Retrospective medical record review.Two free-standing tertiary/quaternary pediatric children's hospitals.Neonates receiving either veno-arterial or veno-venous extracorporeal life support and vancomycin for empiric or definitive therapy with resulting serum concentrations.None.Twelve patients with a median gestations age of 39 weeks (range 36-41 wk) and a median postnatal age of 9.5 days (range 0-28 d) accounted for 14 courses of vancomycin therapy while on extracorporeal life support and were included in the analysis. The median weight was 3.1 kg (range 2.2-4.41 kg) with five of 12 patients (41.7%) being female. Vancomycin concentrations were best described by an one-compartment model incorporating allometric scaling of estimated glomerular filtration rate on clearance. The mean total body clearance (mL/min/kg) for the population was 3.48 ± 1.31 mL/min/kg, and the mean total volume of distribution (L/kg) for the population was 1.2 ± 0.4 L/kg. The intermittent and continuous infusion dosing regimens that provided for the highest percentage of trough concentrations in the range of 10-20 mg/L were the 10 mg/kg/dose IV q8h, 12.5 mg/kg/dose IV q8-12h, 15 mg/kg/dose IV q12h, and 20 mg/kg/dose IV q12h, and the 20, 25, and 30 mg/kg/d continuous infusion regimens, respectively. All regimens allowed for an area under the concentration:minimum inhibitory concentration ratio of 400:1 for minimum inhibitory concentrations of less than or equal to 0.5 mg/L for a 90% PTA. None of the simulated regimens had a greater than 90% probability of achieving an area under the concentration:minimum inhibitory concentration ratio of 400:1 for vancomycin minimum inhibitory concentrations greater than or equal to 1 mg/L while maintaining trough concentrations in the range of 10-20 mg/L.To our knowledge, this is the first pharmacokinetic and pharmacodynamic study of neonates receiving vancomycin with a contemporary ¼-inch extracorporeal life support circuit including the Quadrox-iD Pediatric oxygenator (Maquet Cardiovascular, LLC). The data suggest differences in vancomycin pharmacokinetics compared with previous extracorporeal life support data, notably a more rapid clearance, which could result in lower vancomycin concentrations. Considering this, a more aggressive initial dosing regimen may need to be employed in infants on extracorporeal life support." @default.
• W2717967574 created "2017-06-30" @default.
• W2717967574 creator A5008093438 @default.
• W2717967574 creator A5008485882 @default.
• W2717967574 creator A5011676174 @default.
• W2717967574 creator A5025910111 @default.
• W2717967574 creator A5058570166 @default.
• W2717967574 creator A5070622483 @default.
• W2717967574 date "2017-10-01" @default.
• W2717967574 modified "2023-09-26" @default.
• W2717967574 title "Population Pharmacokinetics and Pharmacodynamic Target Attainment of Vancomycin in Neonates on Extracorporeal Life Support" @default.
• W2717967574 cites W145838624 @default.
• W2717967574 cites W1582744660 @default.
• W2717967574 cites W1965998468 @default.
• W2717967574 cites W1966076267 @default.
• W2717967574 cites W1989630422 @default.
• W2717967574 cites W1990935230 @default.
• W2717967574 cites W1998410651 @default.
• W2717967574 cites W2009505981 @default.
• W2717967574 cites W2017046795 @default.
• W2717967574 cites W2021298363 @default.
• W2717967574 cites W2027478669 @default.
• W2717967574 cites W2028169157 @default.
• W2717967574 cites W2035387676 @default.
• W2717967574 cites W2048097994 @default.
• W2717967574 cites W2056829631 @default.
• W2717967574 cites W2062328478 @default.
• W2717967574 cites W2066543180 @default.
• W2717967574 cites W2082862154 @default.
• W2717967574 cites W2092993969 @default.
• W2717967574 cites W2097815992 @default.
• W2717967574 cites W2098816588 @default.
• W2717967574 cites W2103772309 @default.
• W2717967574 cites W2104779095 @default.
• W2717967574 cites W2106443705 @default.
• W2717967574 cites W2108433768 @default.
• W2717967574 cites W2110119221 @default.
• W2717967574 cites W2112790784 @default.
• W2717967574 cites W2117590874 @default.
• W2717967574 cites W2119264013 @default.
• W2717967574 cites W2122527560 @default.
• W2717967574 cites W2122855609 @default.
• W2717967574 cites W2135206411 @default.
• W2717967574 cites W2138697017 @default.
• W2717967574 cites W2142529525 @default.
• W2717967574 cites W2142588350 @default.
• W2717967574 cites W2414766572 @default.
• W2717967574 cites W2541864258 @default.
• W2717967574 cites W4231469375 @default.
• W2717967574 doi "https://doi.org/10.1097/pcc.0000000000001250" @default.
• W2717967574 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28650363" @default.
• W2717967574 hasPublicationYear "2017" @default.
• W2717967574 type Work @default.
• W2717967574 sameAs 2717967574 @default.
• W2717967574 citedByCount "23" @default.
• W2717967574 countsByYear W27179675742017 @default.
• W2717967574 countsByYear W27179675742018 @default.
• W2717967574 countsByYear W27179675742019 @default.
• W2717967574 countsByYear W27179675742020 @default.
• W2717967574 countsByYear W27179675742021 @default.
• W2717967574 countsByYear W27179675742022 @default.
• W2717967574 countsByYear W27179675742023 @default.
• W2717967574 crossrefType "journal-article" @default.
• W2717967574 hasAuthorship W2717967574A5008093438 @default.
• W2717967574 hasAuthorship W2717967574A5008485882 @default.
• W2717967574 hasAuthorship W2717967574A5011676174 @default.
• W2717967574 hasAuthorship W2717967574A5025910111 @default.
• W2717967574 hasAuthorship W2717967574A5058570166 @default.
• W2717967574 hasAuthorship W2717967574A5070622483 @default.
• W2717967574 hasConcept C111113717 @default.
• W2717967574 hasConcept C112705442 @default.
• W2717967574 hasConcept C126322002 @default.
• W2717967574 hasConcept C139254425 @default.
• W2717967574 hasConcept C141071460 @default.
• W2717967574 hasConcept C159641895 @default.
• W2717967574 hasConcept C2777288759 @default.
• W2717967574 hasConcept C2778980435 @default.
• W2717967574 hasConcept C2779489039 @default.
• W2717967574 hasConcept C2779915274 @default.
• W2717967574 hasConcept C2908647359 @default.
• W2717967574 hasConcept C42219234 @default.
• W2717967574 hasConcept C523546767 @default.
• W2717967574 hasConcept C54355233 @default.
• W2717967574 hasConcept C71924100 @default.
• W2717967574 hasConcept C86803240 @default.
• W2717967574 hasConcept C99454951 @default.
• W2717967574 hasConceptScore W2717967574C111113717 @default.
• W2717967574 hasConceptScore W2717967574C112705442 @default.
• W2717967574 hasConceptScore W2717967574C126322002 @default.
• W2717967574 hasConceptScore W2717967574C139254425 @default.
• W2717967574 hasConceptScore W2717967574C141071460 @default.
• W2717967574 hasConceptScore W2717967574C159641895 @default.
• W2717967574 hasConceptScore W2717967574C2777288759 @default.
• W2717967574 hasConceptScore W2717967574C2778980435 @default.
• W2717967574 hasConceptScore W2717967574C2779489039 @default.
• W2717967574 hasConceptScore W2717967574C2779915274 @default.
• W2717967574 hasConceptScore W2717967574C2908647359 @default.
• W2717967574 hasConceptScore W2717967574C42219234 @default.

• next