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• W2718156733 abstract "Background The secondary T790M mutation accounts for more than 50% of acquired tyrosine kinase inhibitor (TKI) resistance in patients with EGFR-mutated non–small-cell lung cancer (NSCLC). Recent reports suggest this resistance mutation may be more common among patients with longer progression-free survival (PFS) on first-line TKI therapy, but much is still unknown. Materials and Methods Our group collected medical records from patients who underwent a biopsy for T790M mutation testing while screening for clinical trials involving the drug rociletinib (CO-1686), a T790M mutation–specific TKI. Medical records were retrospectively analyzed for demographic data, PFS, and best response to previous therapies. Results Our patient cohort included 69 T790M+ patients and 28 T790M− patients. Patients who later developed a T790M mutation had a longer PFS on first-line TKI therapy (12.0 vs. 9.0 months, P = .021), but overall response rate (ORR) was the same (75.0% vs. 81.0%, P = .76). There was no difference in PFS on TKI rechallenge (4.0 vs. 3.0 months, P = .94), although there was a trend toward higher ORR in T790M+ patients (22.2% vs. 0%, P = .12). T790M+ patients had a longer PFS on initial chemotherapy treatment (5.0 vs. 4.0 months, P = .025) and a trend toward higher ORR (40.0% vs. 21.4%, P = .31). Conclusion Our study confirms that tumors expressing T790M have a more indolent progression of disease compared with their T790M− counterparts when treated with both first-line TKI and cytotoxic chemotherapy." @default.
• W2718156733 created "2017-06-30" @default.
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• W2718156733 date "2018-01-01" @default.
• W2718156733 modified "2023-10-13" @default.
• W2718156733 title "Clinical Implications of the T790M Mutation in Disease Characteristics and Treatment Response in Patients With Epidermal Growth Factor Receptor (EGFR)-Mutated Non–Small-Cell Lung Cancer (NSCLC)" @default.
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• W2718156733 doi "https://doi.org/10.1016/j.cllc.2017.06.004" @default.
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