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- W2718582600 abstract "Calcitonin gene-related peptide (CGRP) is a signaling neuropeptide released from activated trigeminal sensory afferents in headache and facial pain disorders. There are a handful of CGRP-targeted therapies currently in phase 3 studies for migraine acute treatment or prevention. Currently, 4 monoclonal antibodies targeting either the CGRP ligand or receptor are being studied for migraine prevention: ALD403 (eptinezumab), AMG 334 (erenumab), LY2951742 (galcanezumab), and TEV-48125 (fremanezumab). Meanwhile, 1 small-molecule CGRP receptor antagonist (ubrogepant, MK-1602) is currently in phase 3 studies for the acute treatment of migraine. Two of these anti-CGRP monoclonal antibodies are in clinical trials for cluster headache prevention as well. Several other small-molecular CGRP receptor antagonists are in earlier stages of development for acute migraine treatment or prevention. In this review, we will discuss the growing body of clinical trials studying CGRP-targeted therapies for migraine and cluster headache." @default.
- W2718582600 created "2017-06-30" @default.
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- W2718582600 date "2017-07-01" @default.
- W2718582600 modified "2023-10-14" @default.
- W2718582600 title "Calcitonin Gene-Related Peptide-Targeted Therapies for Migraine and Cluster Headache: A Review" @default.
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- W2718582600 doi "https://doi.org/10.1097/wnf.0000000000000227" @default.
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