FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2718740015> ?p ?o ?g. }

• W2718740015 endingPage "685" @default.
• W2718740015 startingPage "675" @default.
• W2718740015 abstract "Individual variation in alcohol consumption in human populations is determined by genetic, environmental, social and cultural factors. In contrast to humans, genetic contributions to complex behavioral phenotypes can be readily dissected in Drosophila , where both the genetic background and environment can be controlled and behaviors quantified through simple high‐throughput assays. Here, we measured voluntary consumption of ethanol in ∼3000 individuals of each sex from an advanced intercross population derived from 37 lines of the Drosophila melanogaster Genetic Reference Panel. Extreme quantitative trait loci mapping identified 385 differentially segregating allelic variants located in or near 291 genes at P < 10 −8 . The effects of single nucleotide polymorphisms associated with voluntary ethanol consumption are sex‐specific, as found for other alcohol‐related phenotypes. To assess causality, we used RNA interference knockdown or P{MiET1} mutants and their corresponding controls and functionally validated 86% of candidate genes in at least one sex. We constructed a genetic network comprised of 23 genes along with a separate trio and a pair of connected genes. Gene ontology analyses showed enrichment of developmental genes, including development of the nervous system. Furthermore, a network of human orthologs showed enrichment for signal transduction processes, protein metabolism and developmental processes, including nervous system development. Our results show that the genetic architecture that underlies variation in voluntary ethanol consumption is sexually dimorphic and partially overlaps with genetic factors that control variation in feeding behavior and alcohol sensitivity. This integrative genetic architecture is rooted in evolutionarily conserved features that can be extrapolated to human genetic interaction networks." @default.
• W2718740015 created "2017-06-30" @default.
• W2718740015 creator A5038750359 @default.
• W2718740015 creator A5049109293 @default.
• W2718740015 creator A5053024731 @default.
• W2718740015 creator A5059714243 @default.
• W2718740015 creator A5060460555 @default.
• W2718740015 creator A5087270789 @default.
• W2718740015 creator A5089353484 @default.
• W2718740015 date "2017-07-21" @default.
• W2718740015 modified "2023-10-15" @default.
• W2718740015 title "Genetics of alcohol consumption in<i>Drosophila melanogaster</i>" @default.
• W2718740015 cites W1511467674 @default.
• W2718740015 cites W1547613518 @default.
• W2718740015 cites W1549086489 @default.
• W2718740015 cites W1571771118 @default.
• W2718740015 cites W1585065066 @default.
• W2718740015 cites W1844068282 @default.
• W2718740015 cites W1854999641 @default.
• W2718740015 cites W1877601466 @default.
• W2718740015 cites W1965385210 @default.
• W2718740015 cites W1968050693 @default.
• W2718740015 cites W1968859985 @default.
• W2718740015 cites W1969230606 @default.
• W2718740015 cites W1976194946 @default.
• W2718740015 cites W1977467968 @default.
• W2718740015 cites W1979803024 @default.
• W2718740015 cites W1983535676 @default.
• W2718740015 cites W1985591441 @default.
• W2718740015 cites W1987119564 @default.
• W2718740015 cites W1990979687 @default.
• W2718740015 cites W1992290174 @default.
• W2718740015 cites W1999503885 @default.
• W2718740015 cites W2005651592 @default.
• W2718740015 cites W2011133239 @default.
• W2718740015 cites W2015998085 @default.
• W2718740015 cites W2021743398 @default.
• W2718740015 cites W2022605219 @default.
• W2718740015 cites W2039013541 @default.
• W2718740015 cites W2046070694 @default.
• W2718740015 cites W2054021169 @default.
• W2718740015 cites W2056366494 @default.
• W2718740015 cites W2063336361 @default.
• W2718740015 cites W2069412262 @default.
• W2718740015 cites W2071206597 @default.
• W2718740015 cites W2079127507 @default.
• W2718740015 cites W2079943120 @default.
• W2718740015 cites W2082867955 @default.
• W2718740015 cites W2102907886 @default.
• W2718740015 cites W2103441770 @default.
• W2718740015 cites W2103740237 @default.
• W2718740015 cites W2105039688 @default.
• W2718740015 cites W2108234281 @default.
• W2718740015 cites W2113244577 @default.
• W2718740015 cites W2117925179 @default.
• W2718740015 cites W2118049762 @default.
• W2718740015 cites W2120999642 @default.
• W2718740015 cites W2122683221 @default.
• W2718740015 cites W2126397413 @default.
• W2718740015 cites W2137516476 @default.
• W2718740015 cites W2140396281 @default.
• W2718740015 cites W2142004009 @default.
• W2718740015 cites W2142976556 @default.
• W2718740015 cites W2147425235 @default.
• W2718740015 cites W2150972545 @default.
• W2718740015 cites W2155844269 @default.
• W2718740015 cites W2156075933 @default.
• W2718740015 cites W2157765869 @default.
• W2718740015 cites W2158217645 @default.
• W2718740015 cites W2160373707 @default.
• W2718740015 cites W2162889729 @default.
• W2718740015 cites W2163965551 @default.
• W2718740015 cites W2168133698 @default.
• W2718740015 cites W2169226435 @default.
• W2718740015 cites W2171521578 @default.
• W2718740015 cites W2344842263 @default.
• W2718740015 cites W2414173527 @default.
• W2718740015 cites W2527820839 @default.
• W2718740015 cites W2530382449 @default.
• W2718740015 cites W2566451247 @default.
• W2718740015 cites W4247053599 @default.
• W2718740015 cites W571397748 @default.
• W2718740015 doi "https://doi.org/10.1111/gbb.12399" @default.
• W2718740015 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5667673" @default.
• W2718740015 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28627812" @default.
• W2718740015 hasPublicationYear "2017" @default.
• W2718740015 type Work @default.
• W2718740015 sameAs 2718740015 @default.
• W2718740015 citedByCount "15" @default.
• W2718740015 countsByYear W27187400152018 @default.
• W2718740015 countsByYear W27187400152019 @default.
• W2718740015 countsByYear W27187400152020 @default.
• W2718740015 countsByYear W27187400152021 @default.
• W2718740015 countsByYear W27187400152022 @default.
• W2718740015 crossrefType "journal-article" @default.
• W2718740015 hasAuthorship W2718740015A5038750359 @default.
• W2718740015 hasAuthorship W2718740015A5049109293 @default.
• W2718740015 hasAuthorship W2718740015A5053024731 @default.

• next