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• W2719150813 startingPage "86" @default.
• W2719150813 abstract "A rare depsipeptide, chaetomiamide A (1), together with two known diketopiperazines (2, 3) were isolated from the cultures of endophytic fungus Chaetomium sp., which was isolated from the root of Cymbidium goeringii. Compound 1 represents a rare skeleton with a 13-membered ring system. It structure was established on the basis of spectroscopic data interpretation. The configuration of 1 was determined by NOESY and Marfey's analysis. These isolates were evaluated for anticancer activity and 3 displayed more potent cytotoxicity than the positive control cisplatin associated with G2/M cell cycle arrest. In addition, 3 induced apoptosis via caspase-3 induction and PARP cleavage, concomitantly with the increase of Bax and decrease of Bcl-2." @default.
• W2719150813 created "2017-06-30" @default.
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• W2719150813 date "2017-09-01" @default.
• W2719150813 modified "2023-10-15" @default.
• W2719150813 title "Secondary metabolites from endophytic fungus Chaetomium sp. induce colon cancer cell apoptotic death" @default.
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• W2719150813 doi "https://doi.org/10.1016/j.fitote.2017.06.021" @default.
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