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- W2719707867 abstract "Purpose: Almost all patients with epithelial ovarian cancer (EOC) receive chemotherapy and, concurrently, the synthetic steroid hormone dexamethasone to alleviate toxicity. This study was to test the impact of steroid hormones on apoptosis of EOC cells and to identify its mediators. Merthods: Microarray with 8K cDNA chips including apoptosis-relevant genes was used to study genes regulated by glucocorticoids in 2 representative EOC cell lines. Cells were incubated with dexamethasone at serum equivalent doses in hormone-depleted medium. Apoptosis was induced by application of TRAIL and determined by caspase 3 activity, PARP cleavage and cell survival. Results: In cell culture, apoptosis was reduced after treatment with dexamethasone or cortisol. Microarray analysis revealed a 7-fold upregulation of the key caspase inhibitor cIAP2 by dexamethasone. cIAP2 upregulation by glucocorticoids was confirmed by RT-PCR and Western blot analysis. Under clinical conditions, we observed significant upregulation of cIAP2 in the ascites cells of an ovarian cancer patient after treatment with dexamethasone. Conclusions: Activation of the glucocorticoid receptor in EOC cells caused an anti-apoptotic effect in EOC cells by enhancing the cellular expression level of cIAP2. Dexamethasone pretreatment of EOC patients receiving apoptosis-inducing therapy raises questions about a negative effect on anti-tumor efficacy." @default.
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- W2719707867 date "2005-10-18" @default.
- W2719707867 modified "2023-10-14" @default.
- W2719707867 title "Microarray analysis of apoptosis-relevant genes modulated by glucocorticoids in ovarian cancer" @default.
- W2719707867 doi "https://doi.org/10.1055/s-2005-921014" @default.
- W2719707867 hasPublicationYear "2005" @default.
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